Li et al developed a multilevel covariance regression (MCR) model as an extension of the covariance regression model of Hoff and Niu. This model assumes a hierarchical structure for the mean and the covariance matrix. Here, we propose the combined multilevel factor analysis and covariance regression model in a Bayesian framework, simultaneously modeling the MCR model and a multilevel factor analysis (MFA) model. The proposed model replaces the responses in the MCR part with the factor scores coming from an MFA model. Via a simulation study and the analysis of real data, we show that the proposed model is quite efficient when the responses of the MCR model are not measured directly but are latent variables such as the patient experience measurements in our motivating dataset.
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http://dx.doi.org/10.1002/sim.9768 | DOI Listing |
Stat Methods Med Res
January 2025
CITMAga and Department of Statistics and Operations Research, Universidade de Vigo, Vigo, Galicia, Spain.
The study of the predictive ability of a marker is mainly based on the accuracy measures provided by the so-called confusion matrix. Besides, the area under the receiver operating characteristic curve has become a popular index for summarizing the overall accuracy of a marker. However, the nature of the relationship between the marker and the outcome, and the role that potential confounders play in this relationship could be fundamental in order to extrapolate the observed results.
View Article and Find Full Text PDFTherap Adv Gastroenterol
January 2025
The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, 16 Zhujilu Road, Guangzhou, Guangdong 510010, China.
Background: Alkaline phosphatase (ALP) is a potential cancer biomarker. However, its prognostic value in patients with colorectal liver metastasis remains unclear.
Objectives: This study aimed to investigate the association between ALP levels and mortality risk in patients with colorectal liver metastases (CRLM), providing insights for enhancing prognostic assessments.
Front Med (Lausanne)
January 2025
Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Background: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver condition in children, underscoring the urgent need for non-invasive markers for early detection in this population.
Methods: We utilized survey data from the National Health and Nutrition Examination Survey (NHANES) 2017-2020 regarding liver ultrasound transient elastography (LUTE) for the diagnosis of NAFLD (dependent variable), and used multiple logistic regression models to explore the association between weight-adjusted waist circumference index (WWI) and the prevalence of NAFLD in US adolescents. Smoothing curves and threshold effect analyses were used to assess the non-linear association between the independent variables and the dependent variable.
Front Med (Lausanne)
January 2025
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Background: Hyperuricemia is the underlying condition of gout. Previous studies have indicated that specific strategies may be effective in preventing the progression of hyperuricemia to gout. However, there is a lack of widely applicable methods for identifying high-risk populations for gout.
View Article and Find Full Text PDFAJOG Glob Rep
February 2025
Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL (Steinberg, Young, Strom, Andebrhan, Perry, Barry, Holder, Roque, and Yee).
Background: In obstetrics and gynecology (OBGYN) research, gender disparities permeate through leadership, funding, promotion, mentorship, publishing, compensation, and publicity. Few studies have investigated OBGYN clinical trial leadership as it relates to investigator gender. Thus, we undertook an investigation of principal investigator (PI) gender and clinical trial success.
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