The development of bio-inks capable of being 3D-printed into cell-containing bio-fabricates with sufficient shape fidelity is highly demanding. Structural integrity and favorable mechanical properties can be achieved by applying high polymer concentrations in hydrogels. Unfortunately, this often comes at the expense of cell performance since cells may become entrapped in the dense matrix. This drawback can be addressed by incorporating fibers as reinforcing fillers that strengthen the overall bio-ink structure and provide a second hierarchical micro-structure to which cells can adhere and align, resulting in enhanced cell activity. In this work, the potential impact of collagen-coated short polycaprolactone-fibers on cells after being printed in a hydrogel is systematically studied. The matrix is composed of eADF4(C16), a recombinant spider silk protein that is cytocompatible but non-adhesive for cells. Consequently, the impact of fibers could be exclusively examined, excluding secondary effects induced by the matrix. Applying this model system, a significant impact of such fillers on rheology and cell behavior is observed. Strikingly, it could be shown that fibers reduce cell viability upon printing but subsequently promote cell performance in the printed construct, emphasizing the need to distinguish between in-print and post-print impact of fillers in bio-inks.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/smtd.202201717 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fabrication of Polytetrafluoroethylene-Reinforced Fluorocarbon Composite Coatings and Tribological Properties Under Multi-Environment Working Conditions.
Polymers (Basel)
December 2024
School of Mechanical and Electrical Engineering, Xi'an University of Architecture and Technology, Xi'an 710055, China.
Currently, few studies have been conducted on the use of fluorocarbon resin (FEVE) and polytetrafluoroethylene (PTFE) as adhesive substrates and lubricating and anti-corrosion fillers, respectively, for the fabrication of PTFE-reinforced fluorocarbon composite coatings. In this paper, the tribological properties of polytetrafluoroethylene-reinforced fluorocarbon composite coatings were investigated through orthogonal tests under various operating conditions. The optimal configuration for coating preparation under dry friction and aqueous lubrication was thus obtained: the optimal filler particle size, mass ratio of FEVE to PTFE, spraying pressure, and curing agent content were 50 μm, 3:4.
View Article and Find Full Text PDFCharacterization of Composites from Post-Consumer Polypropylene and Oilseed Pomace Fillers.
Polymers (Basel)
December 2024
Department of Technology and Entrepreneurship in Wood Industry, Institute of Wood Sciences and Furniture, Warsaw University of Life Sciences-SGGW, 159 Nowoursynowska St., 02-776 Warsaw, Poland.
This study investigates the properties of composites produced using post-consumer polypropylene (PP) reinforced with lignocellulosic fillers from (black cumin) and rapeseed pomace. Using agri-food by-products like pomace supports waste management efforts and reduces the demand for wood in wood-plastic composites. The composite production method combined extrusion and hot flat pressing.
View Article and Find Full Text PDFSynergistic Effect of CNT and N-Doped Graphene Foam on Improving the Corrosion Resistance of Zn Reinforced Epoxy Composite Coatings.
Polymers (Basel)
December 2024
Institute of Advanced Wear & Corrosion Resistant and Functional Materials, Jinan University, Guangzhou 510632, China.
The synergistic effect of CNT and three-dimensional N-doped graphene foam (3DNG) on improving corrosion resistance of zinc-reinforced epoxy (ZRE) composite coatings was studied in this work. Although CNT itself was demonstrated to be effective to promote the anti-corrosion performance of the ZRE coating, the incorporation of additional 3DNG leads to further enhancement of its corrosion resistance under the synergistic effect of the hybrid carbon nanofillers with different dimensions. Both the content of the carbonaceous fillers and the ratio between them affected the performance of the coating.
View Article and Find Full Text PDFChitosan-based dental barrier membrane for periodontal guided tissue regeneration and guided bone regeneration: A review.
Int J Biol Macromol
January 2025
School of Materials and Mineral Resources Engineering, Engineering Campus, Universiti Sains Malaysia, 14300 Nibong Tebal, Penang, Malaysia. Electronic address:
Guided tissue regeneration (GTR) and guided bone regeneration (GBR) are two common dental regenerative procedures used to repair periodontal defects caused by periodontitis. In both procedures, a barrier membrane is placed at the interface between the soft tissue and the periodontal defect, serving to impede the infiltration of soft tissue while creating a secluded space for periodontal regeneration. Recently, barrier membranes based on chitosan (CS) have emerged as a promising avenue for these applications.
View Article and Find Full Text PDFA study based on biochar as a reinforcing agent of irradiated waste thermoplastic composite for polymer engineering and electromagnetic shielding applications.
Environ Technol
January 2025
Solid-State Physics and Accelerators Department, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.
Waste polyethylene (WPE) and virgin polyethylene (VPE) (50:50) thermoplastic have been melt-mixed with biochar (BC) made from orange peels at ratios of 5, 10, and 15(Phr) to evaluate how the filler content affected the mechanical, thermal, optical, electrical conductivity, and electromagnetic interference (EMI). γ-rays was applied to the prepared specimens to assess how radiation affected the created biocomposites. From the obtained results, the combination of BC with γ-rays, at doses of up to 100 kGy, with thermoplastic resulted in an enhanced mechanical property, particularly for composites containing 15 Phr of BC added because of its unique structure and excellent dispersion.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!