AI Article Synopsis
- Tertiary lymphoid structures (TLS) in high-grade serous ovarian cancer (HGSOC) are linked to better survival rates for patients.
- The study found that TLS helps B cells and T cells in the tumor fight cancer more effectively.
- Changes in certain genes can reduce the formation of TLS, and a new method was created to predict the presence of TLS, which helps forecast survival in HGSOC and some lung cancer patients.
Article Abstract
Tertiary lymphoid structure (TLS) is associated with prognosis in copy-number-driven tumors, including high-grade serous ovarian cancer (HGSOC), although the function of TLS and its interaction with copy-number alterations in HGSOC are not fully understood. In the current study, we confirm that TLS-high HGSOC patients show significantly better progression-free survival (PFS). We show that the presence of TLS in HGSOC tumors is associated with B cell maturation and cytotoxic tumor-specific T cell activation and proliferation. In addition, the copy-number loss of IL15 and CXCL10 may limit TLS formation in HGSOC; a list of genes that may dysregulate TLS function is also proposed. Last, a radiomics-based signature is developed to predict the presence of TLS, which independently predicts PFS in both HGSOC patients and immune checkpoint inhibitor (ICI)-treated non-small cell lung cancer (NSCLC) patients. Overall, we reveal that TLS coordinates intratumoral B cell and T cell response to HGSOC tumor, while the cancer genome evolves to counteract TLS formation and function.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394173 | PMC |
| http://dx.doi.org/10.1016/j.xcrm.2023.101092 | DOI Listing |
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