In this study, polylactic acid (PLA) microspheres were used as the raw material to construct bulk implants with surface microtopography through hot pressing and heat treatment, and the microtopographical structures were regulated through the sizes of the PLA microspheres. The surface microtopographies of PLA implants were successfully constructed using micron-sized bulges, which showed a wave-like structure. The ridge width of bulges ranged from 1.64 ± 0.16 µm to 82.52 ± 14.38 µm and the valley depth ranged from 0.49 ± 0.07 µm to 37.35 ± 6.78 µm according to the sizes of microspheres. The nanoindentation tests showed that the modulus and hardness of PLA implants were gradually increased with the decrease in microsphere sizes. The surface microtopography resulted in a slight increase in the hydrophobicity of the PLA implants, but no significant differences were observed. Cells cultured on the implant surface with microtopography exhibited varying morphological responses, and significantly increased osteogenic activity was observed relative to a PLA flat film. This study demonstrated that the surface microtopography derived from PLA microspheres could regulate cellular response and activate osteogenic properties of PLA implants.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.colsurfb.2023.113418 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Decreased Secondary Electron Emission from Aluminum Surface by a Fluorocarbon-Titanium Composite Film.
ACS Omega
December 2024
Naval University of Engineering, Wuhan 430033, China.
Multipactor, a vacuum discharge under microwave conditions triggered by secondary electron emission (SEE), plays a critical role in managing the power level of microwave devices. In this study, we developed a fluorocarbon-titanium composite film on aluminum by cosputtering polytetrafluoroethylene (PTFE) and titanium via a controlled temperature and sputtering power ratio (RF power for PTFE to DC power for Ti) to suppress the SEE of Al. The evolution of microtopography and chemical composition of the composite film was evaluated.
View Article and Find Full Text PDFDominant Role of Surface Peak-Valley Features in Droplet Infiltration Dynamics.
Langmuir
December 2024
Institute of Tribology, Hefei University of Technology, Hefei 230009, China.
In this study, droplet infiltration dynamics on microtextured surfaces is explored to demonstrate the dominant role of surface peak-valley features in the capillary-driven wetting process. Even though two rough surfaces have nearly the same roughness, the microtopography and distribution of surface peaks and valleys may be completely different, leading to variations in liquid infiltration characteristics. Experimental results show that under the same surface roughness ( = 12.
View Article and Find Full Text PDFLaser-Assisted Micropatterned 3D Printed Scaffolds with Customizable Surface Topography and Porosity for Modulation of Cell Function.
Adv Healthc Mater
November 2024
Department of Pharmacology, Pharmacy, and Pharmaceutical Technology, I+D Farma (GI-1645), Facultad de Farmacia, and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain.
The dynamic interaction between cells and their substrate is a cornerstone of biomaterial-based tissue regeneration focused on unraveling the complex factors that govern this crucial relationship. A key challenge is translating physical cues from 2D to 3D due to limitations in current biofabrication techniques. In response, this study introduces an innovative approach that combines additive and subtractive manufacturing for precise surface patterning of 3D printed scaffolds.
View Article and Find Full Text PDFSkin Barrier Function and Microtopography in Patients with Atopic Dermatitis.
J Clin Med
October 2024
Dermatology Department, School of Medicine, University of Granada, 18016 Granada, Spain.
: Atopic dermatitis (AD) is a chronic inflammatory skin disease whose incidence is increasing. Skin barrier dysfunction plays an important role in this disease. It has been observed that AD patients have higher transepidermal water loss (TEWL) and lower stratum corneum hydration (SCH); however, there is little information about skin microtopography in this pathology.
View Article and Find Full Text PDFElectrochemical and imaging evaluations of electrochemically activated screen-printed gold electrodes.
Analyst
November 2024
Institute for Research in Molecular Medicine, (INFORMM), Universiti Sains Malaysia (USM), 11800, Gelugor, Penang, Malaysia.
Sulfuric acid is commonly used to electrochemically activate gold electrodes in a variety of electrochemical applications. This work provides the first evaluations of the electrochemical behaviors and a 3D image of an activated screen-printed gold electrode (SPGE, purchased commercially) through electrochemical and imaging analyses. The activated SPGE surface appears rougher than the unactivated SPGE surface when viewed through microtopography images using scanning electron microscopy (SEM) and atomic force microscopy (AFM).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!