AI Article Synopsis
- Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect multiple organs, and its link to vaccinations, including the SARS-CoV-2 vaccine, is still being studied.
- In a case report, a 53-year-old man was diagnosed with SLE just 9 days after receiving a third dose of the mRNA SARS-CoV-2 vaccine, highlighting a potential connection between vaccination and SLE onset.
- Patients with pre-existing immunological issues or a family history of autoimmune diseases appear to be at higher risk of developing SLE shortly after receiving the vaccine, suggesting type I interferon may play a role in this process.
Article Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease that causes damage to multiple organs. Various factors, including vaccination, have been associated with SLE development. Vaccination for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in 2020, and there are a few reports on the exacerbation of SLE after SARS-CoV-2 vaccination. The influence of SARS-CoV-2 vaccination on SLE development remains unclear. We present the case of a 53-year-old man who developed peritonitis and was subsequently diagnosed with SLE on Day 9 after receiving a third dose of the messenger ribonucleic acid-1273 SARS-CoV-2 vaccine. This case and previous reports have shown that patients who developed SLE after SARS-CoV-2 vaccination are more likely to develop it within 2 weeks of vaccination, especially when they have a higher rate of immunological abnormalities or a family history of autoimmune diseases. Furthermore, these features suggest that type I interferon is involved in the pathogenesis of SLE after SARS-CoV-2 vaccination.
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| http://dx.doi.org/10.1093/mrcr/rxad036 | DOI Listing |
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