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| http://dx.doi.org/10.4103/jisp.jisp_113_23 | DOI Listing |
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CircFNDC3B inhibits vascular smooth muscle cells proliferation in abdominal aortic aneurysms by targeting the miR-1270/PDCD10 axis.
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Maternal and Child Research Institute, Shunde Women and Children's Hospital of Guangdong Medical University, Foshan, P.R. China.
Article Synopsis
- The study explored how a specific circular RNA, circFNDC3B, influences the development of abdominal aortic aneurysm (AAA) by analyzing its expression levels in affected vs. normal tissues.
- Researchers used various assays to understand circFNDC3B's biological functions and molecular mechanisms, confirming that it is significantly more expressed in AAA tissues and has effects on vascular smooth muscle cell behavior.
- The findings indicate that circFNDC3B contributes to AAA progression by acting as a sponge for miR-1270, increasing levels of PDCD10, which is essential for understanding potential therapeutic targets for AAA treatment.
Diagnostic Value of Plasma Long Non-coding SLC26A4 Antisense RNA 1 Combined with Magnetic Resonance Imaging in Rectal Cancer.
Turk J Gastroenterol
November 2024
Department of Radiology, First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Background/aims: The prevalence of rectal cancer is increasing every year due to changes in living and eating habits. Early diagnosis contributes to the treatment and survival of patients. This study investigated the feasibility of employing SLC26A4-AS1 combined with magnetic resonance imaging (MRI) for diagnosing rectal cancer.
View Article and Find Full Text PDFExploring the value in variations of the Relative Income Price (RIP) for calculating cigarette affordability: An illustration using Malaysia.
PLoS One
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Tobacco Control Research Group, Department for Health, University of Bath, Bath, United Kingdom.
The relationships between cigarette affordability, consumer income levels and distribution, and tax increases are complex and underexplored. This study investigates different ways of calculating the Relative Income Price (RIP) measure of affordability using Malaysia as a case study. We calculate cigarette affordability in Malaysia between 2009-2019 using government data, and multiple RIP variants.
View Article and Find Full Text PDFStructural insights into the toxicity of type II ribosome inactivating proteins (RIPs): a molecular dynamics study.
J Biomol Struct Dyn
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Biomolecular Structure and Dynamics Group, Department of Biotechnology, National Institute of Technology, Warangal, India.
Ribosome Inactivating Proteins (RIPs) act by irreversibly depurinating the 28S rRNA ricin-sarcin loop (SRL) of the eukaryotic ribosome resulting in protein synthesis inhibition. In general, they consist of two variants: Type I which is single chained (∼30 kDa), and Type II, a more toxic variant which is a Type I N-glycosidase chain covalently linked to a lectin chain. These proteins are believed to play a pivotal role in defence mechanisms.
View Article and Find Full Text PDFArthroscopy-assisted Minimally Invasive Tarsometatarsal and Lisfranc Arthrodesis. A Case Series.
Ortop Traumatol Rehabil
April 2024
Foot and Ankle Reconstruction/Minimally Invasive Foot and Ankle Surgery, Division of Distal Extremities, Department of Orthopedics, St. Paul's Hospital, The University of British Columbia, Vancouver, BC, Canada.
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- First tarsometatarsal arthrodesis is a surgery used to correct hallux valgus deformities, traditionally done with an open approach, but there's growing interest in arthroscopic and minimally invasive techniques.
- A case series was conducted to explore these techniques on complicated hallux valgus cases, allowing for easier access with specialized tools.
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