The advent of big data technologies makes a profound impact on various facets of our lives, which also presents an opportunity for Chinese audits. However, the heterogeneity of multi-source audit data, the intricacy of converting Chinese into SQL, and the inefficiency of data processing methods present significant obstacles to the growth of Chinese audits. In this article, we proposed BDMCA, a big data management system designed for Chinese audits. We developed a hybrid management architecture for handling Chinese audit big data, that can alleviate the heterogeneity of multi-mode data. Moreover, we defined an R-HBase spatio-temporal meta-structure for auditing purposes, which exhibits almost linear response time and excellent scalability. Compared to MD-HBase, R-HBase performs 4.5× and 3× better in range query and kNN query, respectively. In addition, we leveraged the slot value filling method to generate templates and build a multi-topic presentation learning model MRo-SQL. MRo-SQL outperforms the state-of-the-art X-SQL parsing model with improvements in logical-form accuracy of up to 5.2%, and execution accuracy of up to 5.9%.
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http://dx.doi.org/10.7717/peerj-cs.1317 | DOI Listing |
PLoS Biol
January 2025
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, United States of America.
"Big data" generated from outsourced or centralized facilities often lacks methodological information. Here, we outline how and why researchers, service providers, and other parties should report on methodology and sample metadata to improve scientific reproducibility.
View Article and Find Full Text PDFMethods Mol Biol
January 2025
Department of Food Quality and Nutrition, Research and Innovation Center, Fondazione Edmund Mach, San Michele all'Adige, Italy.
The final aim of metabolomics is the comprehensive and holistic study of the metabolome in biological samples. Therefore, the use of instruments that enable the analysis of metabolites belonging to various chemical classes in a wide range of concentrations is essential, without compromising on robustness, resolution, sensitivity, specificity, and metabolite annotation. These characteristics are crucial for the analysis of very complex samples, such as wine, whose metabolome is the result of the sum of metabolites derived from grapes, yeast(s), bacteria(s), and chemical or physical modification during winemaking.
View Article and Find Full Text PDFElife
January 2025
Institute for Infectious Diseases and Infection Control, Jena University Hospital, Jena, Germany.
Given the rapid cross-country spread of SARS-CoV-2 and the resulting difficulty in tracking lineage spread, we investigated the potential of combining mobile service data and fine-granular metadata (such as postal codes and genomic data) to advance integrated genomic surveillance of the pandemic in the federal state of Thuringia, Germany. We sequenced over 6500 SARS-CoV-2 Alpha genomes (B.1.
View Article and Find Full Text PDFAlzheimers Dement
January 2025
Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Introduction: Deciphering the diverse molecular mechanisms in living Alzheimer's disease (AD) patients is a big challenge but is pivotal for disease prognosis and precision medicine development.
Methods: Utilizing an optimal transport approach, we conducted graph-based mapping of transcriptomic profiles to transfer AD subtype labels from ROSMAP monocyte samples to ADNI and ANMerge peripheral blood mononuclear cells. Subsequently, differential expression followed by comparative pathway and diffusion pseudotime analysis were applied to each cohort to infer the progression trajectories.
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