AI Article Synopsis

  • Research indicates that metabolic dysfunction plays a role in heart changes due to aortic stenosis, but a significant study on human metabolism hasn't been done yet.
  • In a study involving 519 patients, researchers examined 12 heart function metrics before valve implantation and identified three patterns of heart remodeling, linking these to specific metabolic profiles.
  • A distinctive metabolite score for heart function was found to predict higher death rates post-surgery and was related to overall health issues, emphasizing the need to explore metabolic factors to improve patient outcomes after transcatheter aortic valve placement.

Article Abstract

Background Studies in mice and small patient subsets implicate metabolic dysfunction in cardiac remodeling in aortic stenosis, but no large comprehensive studies of human metabolism in aortic stenosis with long-term follow-up and characterization currently exist. Methods and Results Within a multicenter prospective cohort study, we used principal components analysis to summarize 12 echocardiographic measures of left ventricular structure and function pre-transcatheter aortic valve implantation in 519 subjects (derivation). We used least absolute shrinkage and selection operator regression across 221 metabolites to define metabolic signatures for each structural pattern and measured their relation to death and multimorbidity in the original cohort and up to 2 validation cohorts (N=543 for overall validation). In the derivation cohort (519 individuals; median age, 84 years, 45% women, 95% White individuals), we identified 3 axes of left ventricular remodeling, broadly specifying systolic function, diastolic function, and chamber volumes. Metabolite signatures of each axis specified both known and novel pathways in hypertrophy and cardiac dysfunction. Over a median of 3.1 years (205 deaths), a metabolite score for diastolic function was independently associated with post-transcatheter aortic valve implantation death (adjusted hazard ratio per 1 SD increase in score, 1.54 [95% CI, 1.25-1.90]; <0.001), with similar effects in each validation cohort. This metabolite score of diastolic function was simultaneously associated with measures of multimorbidity, suggesting a metabolic link between cardiac and noncardiac state in aortic stenosis. Conclusions Metabolite profiles of cardiac structure identify individuals at high risk for death following transcatheter aortic valve implantation and concurrent multimorbidity. These results call for efforts to address potentially reversible metabolic biology associated with risk to optimize post-transcatheter aortic valve implantation recovery, rehabilitation, and survival.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356077PMC
http://dx.doi.org/10.1161/JAHA.123.029542DOI Listing

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