AI Article Synopsis
- The study focused on the complications of ultrasound-guided radiofrequency ablation (RFA) in chronic kidney disease (CKD) patients who undergo renal replacement therapy with secondary hyperparathyroidism (SHPT).
- A retrospective analysis of 103 SHPT patients revealed a higher incidence of recurrent laryngeal nerve injury during second RFA sessions, and 27 patients experienced complications after the first session, particularly relating to severe hypocalcemia.
- Key risk factors for complications included age, serum phosphorus levels, alkaline phosphatase (ALP), and the number of ablated nodules, suggesting that longer intervals between treatments might reduce nerve injury risks.
Article Abstract
Objective: To study the complications of ultrasound-guided radiofrequency ablation (RFA) in chronic kidney disease (CKD) patients undergoing renal replacement therapy with secondary hyperparathyroidism (SHPT).
Methods: This retrospective study reviewed the clinical data, including general information, examination results, treatment times, time interval, and postoperative complications, of 103 SHPT patients who received ultrasound-guided RFA treatment from July 2017 to January 2021.
Results: Of 103 patients, 52 required two sessions of RFA within a month. The incidence of recurrent laryngeal nerve injury at the second treatment was significantly higher than that at the first treatment (first session vs. second session, 5.77% vs. 21.15%; = .021). Of all the enrolled 103 patients, 27 suffered complications after the first session of RFA. When we separated patients into complications group and non-complication group, we detected more ablated nodules in the complications group ( = -2.222; = .0026). Subgroup analysis further showed that the patients in the severe hypocalcemia group were younger ( = .005), had more ablated nodules ( = .003) and higher blood phosphorus ( = .012) and alkaline phosphatase (ALP) levels ( = .002). Univariate analysis showed that age, serum phosphorus, ALP, and number of ablated nodules were associated with a higher risk of severe hypocalcemia after the first session of RFA.
Conclusions: An interval of more than 1 month between two treatments may help to avoid recurrent laryngeal nerve injury. Age, serum phosphorus, ALP, and number of ablated nodules were associated with a higher risk of severe hypocalcemia after the first session of RFA.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10288920 | PMC |
| http://dx.doi.org/10.1080/0886022X.2023.2215334 | DOI Listing |
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