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From Fibrosis to Granuloma: Drug Induced Systemic Sarcoidosis-Like Reaction After Rituximab in a Patient with Primary Sjögren's Syndrome.
Eur J Case Rep Intern Med
December 2024
Clínica de Medicina, Serviço de Medicina Interna, Centro Hospitalar Universitário de Santo António, Porto, Portugal.
Unlabelled: Sarcoidosis is a multisystemic syndrome characterized by non-caseous granulomatous inflammation, although necrotizing sarcoid granulomatosis is considered part of the spectrum of the disease. Drug induced sarcoidosis-like reaction (DISR) is a systemic granulomatous reaction, which is histopathologically identical to primary sarcoidosis - mostly described after the use of biologics like tumour necrosis factor alpha antagonists but also anti-CD20 (rituximab). The authors present the very rare case of a woman with a primary Sjögren's syndrome (pSS) started on rituximab for disease control, which evolved with a 3-year indolent progressive systemic sarcoid reaction.
View Article and Find Full Text PDFMutations in ABCA3 can result in surfactant deficiency, leading to respiratory distress syndrome in term neonates, and interstitial lung disease (ILD) in children. Here, we report an extremely rare case of ILD in an identical twin with novel ABCA3 germline mutations. Interestingly, they showed mostly similar, but slightly different, clinical features.
View Article and Find Full Text PDFA 66-year-old male from Myanmar presented with 3 months of cough and constitutional symptoms. He was an ex-tobacco user with no significant medical or exposure history. Chest x-ray showed ill-defined bilateral opacities and a left pleural effusion.
View Article and Find Full Text PDFDefining the course of neurosarcoidosis according to presentation at onset and disease modifying treatment: a cohort study of 84 patients.
Ther Adv Neurol Disord
December 2023
Service de Neurologie, Hopital Central, CHRU de Nancy, 1 Avenue du Maréchal de Lattre de Tassigny, Nancy 54000, France.
Background: Neurosarcoidosis is a rare manifestation of sarcoidosis with heterogeneous presentations. Patient management is challenging due to the current lack of knowledge about the long-term disease course.
Objective: To identify specific disease courses of neurosarcoidosis according to the clinical and paraclinical presentations at onset.
Calcified axillary lymph nodes in a case of de novo metastatic breast cancer.
Radiol Case Rep
January 2024
Moffitt Cancer Center, 10920 McKinley Dr, Tampa, FL, USA.
At the time of a mammogram, calcifications may be seen in axillary lymph nodes. Metastatic breast cancer is the most common malignant cause of calcifications in the axillary lymph nodes. Benign causes may include but are not limited to granulomatous disease, fat necrosis, gold deposits in rheumatoid arthritis patients, pigmentation from tattoos, and sarcoidosis.
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