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Comparing the Effect of DOAC-Stop and DOAC-Remove on Apixaban, Rivaroxaban and Dabigatran Prior to Thrombophilia and Lupus Testing.
Br J Biomed Sci
November 2024
Department of Haematology, Northumbria Healthcare NHS Foundation Trust, North Shields, United Kingdom.
Background: Direct oral anticoagulants (DOACs) interfere with coagulation assays potentially leading to inaccurate results. This study determined the effectiveness of DOAC-stop® and DOAC-remove® in overcoming DOAC interference. It aimed to investigate the extent to which apixaban, rivaroxaban, and dabigatran had an effect on thrombophilia and lupus tests using normal plasma, as well as whether DOACs interfere with true-positive results by testing abnormal controls.
View Article and Find Full Text PDFSimplified Method for Removing Direct Oral Anticoagulant Interference in Mechanical Coagulation Test Systems-A Proof of Concept.
J Clin Med
February 2024
Haematology Department, Institute of Clinical Pathology and Medical Research (ICPMR), Sydney Centres for Thrombosis and Haemostasis, Westmead Hospital, Sydney, NSW 2145, Australia.
Background: Direct oral anticoagulants (DOACs) cause unwanted interference in various hemostasis assays, including lupus anticoagulant (LA) testing, where false positive and false negative identification may occur. DOAC Stop (DS) is an activated charcoal (AC) product used to specifically and effectively adsorb DOACs from test plasma. This process normally requires plasma treatment, centrifugation and plasma separation prior to tests, but inexperienced operators may also inadvertently transfer residual AC particles, thereby potentially adversely affecting clot detection.
View Article and Find Full Text PDFEffects of DOAC-Stop on clot waveform analysis of plasma spiked with antithrombin-dependent and antithrombin-independent anticoagulants.
Int J Lab Hematol
December 2023
Department of Laboratory Medicine, Keio University School of Medicine, Tokyo, Japan.
The methods for removal of direct oral anticoagulants and heparins to improve the monitoring of hemostasis: a narrative literature review.
Thromb J
May 2023
Department of Pharmacodynamics, Medical University of Bialystok, Bialystok, Poland.
The assessment of hemostasis is necessary to make suitable decisions on the management of patients with thrombotic disorders. In some clinical situations, for example, during thrombophilia screening, the presence of anticoagulants in sample makes diagnosis impossible. Various elimination methods may overcome anticoagulant interference.
View Article and Find Full Text PDFDirect oral anticoagulant adsorption and laboratory detection of lupus anticoagulant.
Blood Coagul Fibrinolysis
April 2023
Laboratory Analysis, Azienda Ospedaliera Ordine Mauriziano, Turin, Italy.
Unlabelled: Direct oral anticoagulants (DOACs) interfere with many coagulation assays, mostly in lupus anticoagulant (LA) detection, causing false positive and negative results. Despite guidelines recommendations, LA testing may be important during anticoagulation when the clinician has to decide whether to prolong or discontinue the drug.
Objectives: In this study, the effect of activated charcoal (DOAC-Stop, DS) as a DOAC-adsorbent was investigated on samples from DOACs treated and untreated patients.
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