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When death is desired: A case of MAiD & the CL psychiatrist.
Palliat Support Care
January 2025
Department of Psychiatry, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Objectives: Since physician-assisted dying (PAD) has become a part of the clinical dialogue in the United States (US) and other Western countries, it has spawned controversy in the moral, ethical, and legal realm, with significant cross-country variation. The phenomenon of PAD includes 2 practices: Euthanasia and medical aid in dying (MAiD). Although euthanasia has been allowed in different parts of the world, in the US it is illegal.
View Article and Find Full Text PDFAsthma Biologics Across the T2 Spectrum of Inflammation in Severe Asthma: Biomarkers and Mechanism of Action.
J Asthma Allergy
January 2025
Amgen Inc., Thousand Oaks, CA, USA.
Airway inflammation, a hallmark feature of asthma, drives many canonical features of the disease, including airflow limitation, mucus plugging, airway remodeling, and hyperresponsiveness. The T2 inflammatory paradigm is firmly established as the dominant mechanism of asthma pathogenesis, largely due to the success of inhaled corticosteroids and biologic therapies targeting components of the T2 pathway, including IL-4, IL-5, IL-13, and thymic stromal lymphopoietin (TSLP). However, up to 30% of patients may lack signatures of meaningful T2 inflammation (ie, T2 low).
View Article and Find Full Text PDFThe Importance and Discovery of Highly Connected Covalent Organic Framework Net Topologies.
J Am Chem Soc
January 2025
Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.
Furthering the field of synthetic organic chemistry from the discrete molecules regime to the extended structure regime, covalent organic frameworks (COFs) represent a new genre of crystalline porous materials featuring designability with molecular-level precision, well-defined porosity, and exceptional stability imparted by the robust covalent linkages reticulating organic molecules. The topology of COFs is a principal feature that regulates their functionality and usability for emerging technologies. Profound comprehension of network topologies and maneuvering them toward targeted applications are crucial to advancing the realm of COF research and developing novel functional materials for exciting breakthroughs.
View Article and Find Full Text PDFDeciphering the roles of non-coding RNAs in liposarcoma development: Challenges and opportunities for translational therapeutic advances.
Noncoding RNA Res
April 2025
China-ASEAN College of Marine Sciences, Xiamen University Malaysia, 43900, Sepang, Selangor, Malaysia.
Liposarcoma is one of the most prevalent forms of soft tissue sarcoma, and its prognosis is highly dependent on its molecular subtypes. Non-coding RNAs (ncRNAs) like microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) can bind various cellular targets to regulate carcinogenesis. By affecting the expressions and activities of their downstream targets post-transcriptionally, dysregulations of miRNAs can alter different oncogenic signalling pathways, mediating liposarcoma progression.
View Article and Find Full Text PDFAbiotic Factors Modulating Metabolite Composition in Brown Algae (Phaeophyceae): Ecological Impacts and Opportunities for Bioprospecting of Bioactive Compounds.
Mar Drugs
December 2024
Laboratory of Natural Products from Seaweeds (ALGAMAR), Department of Marine Biology, Institute of Biology, Federal Fluminense University, Niterói 24210-201, RJ, Brazil.
Brown algae are vital structural elements and contributors to biodiversity in marine ecosystems. These organisms adapt to various environmental challenges by producing primary and secondary metabolites crucial for their survival, defense, and resilience. Besides their ecological role, these diverse metabolites have potential for biotechnological applications in industries including pharmaceuticals, cosmetics, and food.
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