Organoids as a tool in drug discovery and patient-specific therapy for head and neck cancer.

Cell Rep Med

Department of Otolaryngology - Head & Neck Surgery, University of California - Davis, Sacramento, CA, USA. Electronic address:

Published: June 2023

AI Article Synopsis

  • Organoids are better models of the tumor microenvironment compared to traditional methods.
  • Millen et al. showed that patient-derived organoids can predict how individual patients will respond to radiation therapy.
  • These organoids could also be useful for validating biomarkers in drug discovery and treatment planning.

Article Abstract

Organoids more accurately reflect tumor microenvironment than traditional models. Millen et al. demonstrated organoids replicated from patient tissues may predict patient-specific response to radiation therapy and have potential to be utilized for validation of biomarkers in drug discovery and treatment planning.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10314095PMC
http://dx.doi.org/10.1016/j.xcrm.2023.101087DOI Listing

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