Background: Solute carrier family 22 member 3 () gene had been reported to be associated with the efficacy of metformin in type 2 diabetes mellitus (T2DM). However, few studies reported the relationship between polymorphism and T2DM. The aim of this study was to investigate the association of polymorphism and susceptibility to T2DM in Chinese population.
Methods: We identified rs555754, rs3123636, rs3088442 genotypes of 450 T2DM patients and 220 healthy controls from the Chinese population. The association between SNPs of and susceptibility of T2DM was evaluated.
Results: The clinical characteristics were significantly different between T2DM patients and healthy controls. The polymorphisms of rs555754 and rs3123636 were obviously associated with the susceptibility of T2DM which was adjusted for age, sex and BMI, while rs3088442 did not. And there was haplotype association of rs3088442-rs3123636 with T2DM susceptibility.
Conclusion: rs555754 and rs3123636 polymorphisms were associated with the susceptibility to T2DM in Chinese Han population. Large sample size studies would be required to verify this association.
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| http://dx.doi.org/10.2147/DMSO.S412857 | DOI Listing |
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