Synthesis of the Hexasaccharide Related to the Exopolysaccharide from VG1 through Regioselective Glycosylation.

Chemical synthesis of the hexasaccharide repeating unit associated with the exopolysaccharide of VG1 is reported. The total synthesis is accomplished through a convergent [2 + 2 + 2] strategy using rationally protected monosaccharide derivatives. Chemoselective activation of the glycosyl donors and regioselective nucleophilicity of the acceptors were successfully employed throughout the chemical synthesis.