AI Article Synopsis
- Plastids have become a key platform in plant synthetic biology for producing valuable secondary metabolites and therapeutic proteins, offering advantages over traditional nuclear genetic engineering.
- Constitutive expression of foreign genes in plastids can negatively affect plant growth, highlighting the need for better regulatory mechanisms to control gene expression.
- The review highlights advancements in regulatory elements for plastid genetic engineering, such as operon design, multi-gene coexpression strategies, and new regulatory elements, paving the way for future research.
Article Abstract
With the advancement of plant synthetic biology, plastids have emerged as an optimal platform for the heterologous production of numerous commercially valuable secondary metabolites and therapeutic proteins. In comparison on nuclear genetic engineering, plastid genetic engineering offers unique advantages in terms of efficient expression of foreign genes and biological safety. However, the constitutive expression of foreign genes in the plastid system may impede plant growth. Therefore, it is imperative to further elucidate and design regulatory elements that can achieve precise regulation of foreign genes. In this review, we summarize the progress made in developing regulatory elements for plastid genetic engineering, including operon design and optimization, multi-gene coexpression regulation strategies, and identification of new expression regulatory elements. These findings provide valuable insights for future research.
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| http://dx.doi.org/10.16288/j.yczz.23-021 | DOI Listing |
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