-methyladenosine (mA) is one of the most abundant chemical modifications in mRNA and plays essential roles in diverse physiological and pathological processes. mA is highly enriched near stop codons and in long internal exons of mRNA, but the mechanism leading to this specific distribution has been unclear. Recently, three papers have solved this major problem by revealing that exon junction complexes (EJCs) act as mA suppressors and shape the formation of the mA epitranscriptome. Here, we briefly introduce the mA pathway, elaborate the roles of EJC on the formation of mA modification based on these results, and describe the effect of exon-intron structure on mRNA stability mA, which will help us better understand the latest progress in the mA RNA modification field.
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| http://dx.doi.org/10.16288/j.yczz.23-051 | DOI Listing |
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