Treating each training sample unequally is prevalent in many machine-learning tasks. Numerous weighting schemes have been proposed. Some schemes take the easy-first mode, whereas others take the hard-first one. Naturally, an interesting yet realistic question is raised. Given a new learning task, which samples should be learned first, easy or hard? To answer this question, both theoretical analysis and experimental verification are conducted. First, a general objective function is proposed and the optimal weight can be derived from it, which reveals the relationship between the difficulty distribution of the training set and the priority mode. Two novel findings are subsequently obtained: besides the easy-first and hard-first modes, there are two other typical modes, namely, medium-first and two-ends-first; the priority mode may be varied if the difficulty distribution of the training set changes greatly. Second, inspired by the findings, a flexible weighting scheme (FlexW) is proposed for selecting the optimal priority mode when there is no prior knowledge or theoretical clues. The four priority modes can be flexibly switched in the proposed solution, thus suitable for various scenarios. Third, a wide range of experiments is conducted to verify the effectiveness of our proposed FlexW and further compare the weighting schemes in different modes under various learning scenarios. On the basis of these works, reasonable and comprehensive answers are obtained for the easy-or-hard question.
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http://dx.doi.org/10.1109/TNNLS.2023.3284430 | DOI Listing |
Geriatrics (Basel)
December 2024
Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle-upon-Tyne NE1 8ST, UK..
Despite an established evidence-base for cardiac rehabilitation (CR) improving functional outcomes and quality of life and reducing re-hospitalisation, there is limited research on CR for older cardiac patients, who require rehabilitation the most, as they are often very deconditioned due to aortic stenosis (AS). CR uptake in the UK is limited to 52% with national variability of provision and accessibility, and it is a national priority to increase uptake to 85%. Frequently, research has excluded older populations as they are deemed to be too frail or generally not suitable for inclusion.
View Article and Find Full Text PDFNat Commun
December 2024
Institute of Physiological Chemistry, Faculty of Medicine, Philipps University of Marburg, Marburg, Germany.
Mirror-image proteins, composed of D-amino acids, are an attractive therapeutic modality, as they exhibit high metabolic stability and lack immunogenicity. Development of mirror-image binding proteins is achieved through chemical synthesis of D-target proteins, phage display library selection of L-binders and chemical synthesis of (mirror-image) D-binders that consequently bind the physiological L-targets. Monobodies are well-established synthetic (L-)binding proteins and their small size (~90 residues) and lack of endogenous cysteine residues make them particularly accessible to chemical synthesis.
View Article and Find Full Text PDFScand J Clin Lab Invest
December 2024
INOVIE BIOFUTUR laboratory (Inovie member), Paris, France.
Introduction: Verification and validation of analytical methods are crucial aspects of quality assurance in a laboratory. This study aimed to develop a risk analysis and assessment tool to streamline the process of identifying so-called 'sentinel' tests.
Materials And Methods: The Roche Cobas 8000 systems were evaluated to analyze 83 serum analytes, including routine chemistry, immunoassays, and therapeutic drugs.
Polymers (Basel)
November 2024
Civil Engineering Institute, Peter the Great St. Petersburg Polytechnic University, Polytechnicheskaya, 29 B, 195251 St. Petersburg, Russia.
The development of nanofibers with incorporated biologically active molecules with a targeted mode of action is a current research trend. Potential materials for the development of such systems include poly(vinyl alcohol) (PVA) and chitosan (CS) nanofibers, which are traditionally fabricated by the electrospinning of aqueous solutions of these polymers with acetic acid. To improve drug integration, ethanol was added to the binary-solvent system.
View Article and Find Full Text PDFJ Glob Antimicrob Resist
December 2024
Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Department of Clinical Analysis, School of Pharmacy, University of São Paulo, São Paulo, Brazil; One Health Brazilian Resistance Project (OneBR), São Paulo, Brazil. Electronic address:
Objectives: Critical priority carbapenem-resistant pathogens constitute a worldwide public health problem. Escherichia coli ST1193 is an emerging high-risk clone that demonstrates prolonged gut persistence, and association with community-onset urinary and bloodstream infections. The purpose of this study is to report microbiological and genomic data on the emergence of KPC-2-producing E.
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