Brain Connectivity in Dystonia: Evidence from Magnetoencephalography.

Adv Neurobiol

Department of Neurological Sciences, Rush Parkinson's Disease and Movement Disorders Program, Chicago, IL, USA.

Published: June 2023

Magnetoencephalography (MEG) detects synchronized activity within a neuronal network by measuring the magnetic field changes generated by intracellular current flow. Using MEG data, we can quantify brain region networks with similar frequency, phase, or amplitude of activity and thereby identify patterns of functional connectivity seen with specific disorders or disease states. In this review, we examine and summarize MEG-based literature on functional networks in dystonias. Specifically, we inspect literature evaluating the pathogenesis of focal hand dystonia, cervical dystonia, embouchure dystonia, the effects of sensory tricks, treatment with botulinum toxin and deep brain stimulation, and rehabilitation approaches. This review additionally highlights how MEG has potential for application to clinical care of patients with dystonia.

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http://dx.doi.org/10.1007/978-3-031-26220-3_8DOI Listing

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