Methods for decomposition analyses have been developed to partition between-group differences into explained and unexplained portions. In this paper, we introduce the concept of causal decomposition maps, which allow researchers to test the effect of area-level interventions on disease maps before implementation. These maps quantify the impact of interventions that aim to reduce differences in health outcomes between groups and illustrate how the disease map might change under different interventions. We adapt a new causal decomposition analysis method for the disease mapping context. Through the specification of a Bayesian hierarchical outcome model, we obtain counterfactual small area estimates of age-adjusted rates and reliable estimates of decomposition quantities. We present two formulations of the outcome model, with the second allowing for spatial interference of the intervention. Our method is utilized to determine whether the addition of gyms in different sets of rural ZIP codes could reduce any of the rural-urban difference in age-adjusted colorectal cancer incidence rates in Iowa ZIP codes.
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http://dx.doi.org/10.1002/bimj.202200213 | DOI Listing |
Viruses
December 2024
Life Sciences, Health, and Engineering Department, The Roux Institute, Northeastern University, Portland, ME 04101, USA.
JC polyomavirus (JCPyV) establishes a persistent, asymptomatic kidney infection in most of the population. However, JCPyV can reactivate in immunocompromised individuals and cause progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease with no approved treatment. Mutations in the hypervariable non-coding control region (NCCR) of the JCPyV genome have been linked to disease outcomes and neuropathogenesis, yet few metanalyses document these associations.
View Article and Find Full Text PDFBMC Microbiol
January 2025
College of Tobacco Science/Research Center for Tobacco Harm Reduction/Tobacco Cultivation Key Laboratory of China Tobacco, Henan Agricultural University, Zhengzhou, Henan, 450002, People's Republic of China.
Objective: This study explored green manuring effects on microecology, carbon/nitrogen levels, and enzyme activity in tobacco-growing soils.
Methods: After 30,000 kg·hm⁻² overpressure and 28 days of natural decomposition, plants (Hordeum vulgare L. (DM), Secale cereale L.
BMC Public Health
January 2025
Department of Statistics and Actuarial Sciences, School of Physical and Mathematical Sciences, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya.
Background: Child malnutrition remains a critical public health problem, with socioeconomic factors playing a significant role. Socioeconomic factors include household income, parental education, and access to healthcare, which influence a child's nutritional status. Despite overall progress in reducing under-five child malnutrition in Kenya, disparities persist.
View Article and Find Full Text PDFAppl Environ Microbiol
January 2025
Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA.
Lignin contains a variety of interunit linkages, leading to a range of potential decomposition products that can be used as carbon and energy sources by microbes. β-O-4 linkages are the most common in native lignin, and associated catabolic pathways have been well characterized. However, the fate of the mono-aromatic intermediates that result from β-O-4 dimer cleavage has not been fully elucidated.
View Article and Find Full Text PDFClin Psychol Sci
November 2024
Department of Psychology, Michigan State University, USA.
Internalizing (e.g., anxiety, depression) and disordered eating (DE; e.
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