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Definitions, Diagnosis and Management of Postoperative Recurrence in Crohn's Disease Patients with Permanent Ileostomy - A Systematic Review and Meta-Analysis.
J Crohns Colitis
March 2025
Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
Background And Aims: Over 10% of patients with Crohn's disease require permanent ileostomy. We aimed to summarize the existing data on diagnosis, definitions of recurrence, and management of Crohn's disease patients with permanent ileostomy.
Methods: MEDLINE, Embase, and CENTRAL databases were searched from inception to February 6, 2024.
Gastrointestinal traits, common inflammatory disorders, gallstones, and biliary tract cancer: A network Mendelian randomization study.
J Adv Res
March 2025
Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun, Jilin, China. Electronic address:
Introduction: Observational studies have shown that gallstone disease (GSD), cholecystitis, cholangitis, polyp of gallbladder, viral hepatitis, pancreatitis and gastrointestinal (GI) traits such as H. pylori infection, inflammatory bowel disease, and digestive ulcer are associated with the risk of biliary tract cancer (BTC). However, no study has explored their causal associations.
View Article and Find Full Text PDFBowel Obstruction Due to the Mesenteric Mass Being an Enteritis Cystica Profunda: A Case Report.
Cureus
February 2025
Hepatobiliary Surgery, Prince Sultan Military Medical City, Riyadh, SAU.
Enteritis cystica profunda (ECP) is a rare benign condition characterized by mucin-filled cystic spaces in the submucosal layer of the small intestine. It is often associated with inflammatory conditions, such as Crohn's disease. This case report describes a 47-year-old male with a history of diabetes and hypertension who presented with flank pain and dysuria.
View Article and Find Full Text PDFStrengths, weaknesses, opportunities, and threats analysis of combination therapy for inflammatory bowel disease.
World J Gastroenterol
March 2025
Department of Clinical Pharmacy, Zunyi Medical University, Zunyi 563006, Guizhou Province, China.
Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, manifests as a chronic, recurrent, and refractory intestinal inflammatory condition significantly impacting patients' quality of life. Despite ongoing research, its etiology and pathogenesis remain incompletely understood. Recent advancements in medical research highlight the critical role of drug combination therapies in managing IBD.
View Article and Find Full Text PDFPerianal fistulizing Crohn's disease: Mechanisms and treatment options focusing on cellular therapy.
World J Gastroenterol
March 2025
Department of Anatomy, Division of Human Biology, School of Medicine, IMU University, Kuala Lumpur 57000, Malaysia.
Perianal fistulizing Crohn's disease (PFCD) is a common presentation of CD, which affects the patients' quality of life, including social and sexual function. The management of PFCD remains a critical challenge in inflammatory bowel disease, primarily due to limited understanding of the mechanisms involved in its pathogenesis, complicating medical treatment. Increased production of inflammatory cytokines such as tumor necrosis factor and interleukin-13 by infiltrating macrophages and other inflammatory cells stimulate the epithelial-to-mesenchymal transition, resulting in activation of myofibroblasts and elevation of matrix metalloproteinases, leading to fistula formation.
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