AI Article Synopsis
- Aberrant alternative splicing (AS) in lung cancer arises from disrupted gene splicing and regulatory factors, leading to cancer progression and resistance.
- This review highlights how AS is crucial in various cancer processes like invasion, metastasis, and angiogenesis, potentially serving as biomarkers for diagnosis and prognosis.
- Understanding AS could offer new strategies for treating lung cancer, providing hope for improved outcomes.
Article Abstract
Aberrant alternative splicing (AS) events are frequently observed in lung cancer, which can be attributed to aberrant gene AS, alterations in splicing regulatory factors, or changes in splicing regulatory mechanisms. Consequently, the dysregulation of alternative RNA splicing is the fundamental cause of lung cancer. In this review, we have summarized the pivotal role of AS in the development, progression, invasion, metastasis, angiogenesis, and drug resistance of lung cancer. Ultimately, this review emphasizes the potential of AS as biomarkers in lung cancer prognosis and diagnosis, and introduces some applications of AS isoform in the treatment of lung cancer. The comprehension of the AS may provide a glimmer of hope for the eradication of lung cancer.
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| http://dx.doi.org/10.1007/s00280-023-04553-4 | DOI Listing |
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