MV140 is a mucosal vaccine of inactivated whole bacteria () with clinical efficacy against recurrent urinary tract infections (UTIs). Here, MV140 was evaluated in a murine model of acute uropathogenic (UPEC)-induced UTI using the UTI89 strain. MV140 vaccination resulted in UPEC clearance, concomitant with increased influx of myeloid cells in urine, CD4+ T cells in the bladder, and a systemic adaptive immune response to both MV140-containing and UTI89.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10275044 | PMC |
| http://dx.doi.org/10.21203/rs.3.rs-2992611/v1 | DOI Listing |
Publication Analysis
Top Keywords
mv140 mucosal
8
urinary tract
8
mv140
4
mucosal bacterial
4
bacterial vaccine
4
vaccine improves
4
improves uropathogenic
4
uropathogenic clearance
4
clearance experimental
4
experimental model
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!