Sensation seeking is bidirectionally associated with levels of alcohol consumption in both adult and adolescent samples and shared neurobiological and genetic influences may in part explain this association. Links between sensation seeking and alcohol use disorder (AUD) may primarily manifest via increased alcohol consumption rather than through direct effects on increasing problems and consequences. Here the overlap between sensation seeking, alcohol consumption, and AUD was examined using multivariate modeling approaches for genome-wide association study (GWAS) summary statistics in conjunction with neurobiologically-informed analyses at multiple levels of investigation. Meta-analytic and genomic structural equation modeling (GenomicSEM) approaches were used to conduct GWAS of sensation seeking, alcohol consumption, and AUD. Resulting summary statistics were used in downstream analyses to examine shared brain tissue enrichment of heritability and genome-wide evidence of overlap (e.g., stratified GenomicSEM, RRHO, genetic correlations with neuroimaging phenotypes) and to identify genomic regions likely contributing to observed genetic overlap across traits (e.g., HMAGMA, LAVA). Across approaches, results supported shared neurogenetic architecture between sensation seeking and alcohol consumption characterized by overlapping enrichment of genes expressed in midbrain and striatal tissues and variants associated with increased cortical surface area. Alcohol consumption and AUD evidenced overlap in relation to variants associated with decreased frontocortical thickness. Finally, genetic mediation models provided evidence of alcohol consumption mediating associations between sensation seeking and AUD. This study extends previous research by examining critical sources of neurogenetic and multi-omic overlap among sensation seeking, alcohol consumption, and AUD which may underlie observed phenotypic associations.
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http://dx.doi.org/10.1101/2023.05.30.23290733 | DOI Listing |
Psychol Addict Behav
January 2025
Department of Psychological and Brain Sciences, University of Louisville.
Objective: Previous research has found that momentary positive affect precedes alcohol use, whereas results have been more mixed for negative affect.
Method: This study replicates and builds upon this literature by using a heavy drinking sample, half lesbian, gay, bisexual, trans, queer/questioning, and other minoritized sexual and gender identities (LGBTQ+) individuals.
Results: This study found that positive affect was related to subsequent alcohol use, but the relation was weaker for LGBTQ+ individuals compared to cisgender-straight individuals.
Psychol Addict Behav
January 2025
Department of Psychology, York University.
Objective: Simultaneous cannabis and alcohol use is common, but few studies have examined normative perceptions of simultaneous use. This study examined unique associations of baseline descriptive norms for simultaneous use (i.e.
View Article and Find Full Text PDFObjective: To understand the influence of acute alcohol consumption on the recall and recognition of warning messages.
Method: Participants ( = 82) were randomly assigned to a condition where they consumed alcoholic beverages (target blood alcohol concentrations of 0.06%-0.
Psychol Addict Behav
January 2025
Edna Bennett Pierce Prevention Research Center, College of Health and Human Development, Pennsylvania State University.
Objective: Transdermal alcohol concentration (TAC) sensors provide a multidimensional characterization of drinking events that self-reports cannot. These profiles may differ in their associated day-level alcohol-related consequences, but no research has tested this. We address this using multilevel latent profile analysis.
View Article and Find Full Text PDFCochrane Database Syst Rev
January 2025
Cochrane Switzerland, c/o Cochrane Germany Foundation, Freiburg, Germany.
Background: Chronic diseases are the leading cause of mortality and morbidity worldwide. Much of this burden can be prevented by adopting healthy behaviours and reducing chronic disease risk factors. Settings-based approaches to address chronic disease risk factors are recommended globally.
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