Embeddings are fundamental resources often reused for building intelligent systems in the biomedical context. As a result, evaluating the quality of previously trained embeddings and ensuring they cover the desired information is critical for the success of applications. This paper proposes a new evaluation methodology to test the coverage of embeddings against a targetted domain of interest. It defines measures to assess the terminology, similarity, and analogy coverage, which are core aspects of the embeddings. Then, it discusses the experimentation carried out on existing biomedical embeddings in the specific context of pulmonary diseases. The proposed methodology and measures are general and may be applied to any application domain.
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http://dx.doi.org/10.1016/j.heliyon.2023.e16818 | DOI Listing |
ACS Nano
January 2025
Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, Changsha 410078, Hunan, China.
Spinal cord injury (SCI) remains a formidable challenge in biomedical research, as the silencing of intrinsic regenerative signals in most spinal neurons results in an inability to reestablish neural circuits. In this study, we found that neurons with low axonal regeneration after SCI showed decreased extracellular signal-regulated kinase (ERK) phosphorylation levels. However, the expression of dual specificity phosphatase 26 (DUSP26)─which negatively regulates ERK phosphorylation─was reduced considerably in neurons undergoing spontaneous axonal regeneration.
View Article and Find Full Text PDFBrief Bioinform
November 2024
Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China.
Clathrin proteins, key elements of the vesicle coat, play a crucial role in various cellular processes, including neural function, signal transduction, and endocytosis. Disruptions in clathrin protein functions have been associated with a wide range of diseases, such as Alzheimer's, neurodegeneration, viral infection, and cancer. Therefore, correctly identifying clathrin protein functions is critical to unravel the mechanism of these fatal diseases and designing drug targets.
View Article and Find Full Text PDFBiol Proced Online
January 2025
Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu, 610041, China.
Archived clinical formalin-fixed paraffin-embedded tissue (FFPE) is valuable for the study of tumor epigenetics. Although protocol of chromatin immunoprecipitation coupled with next generation sequencing (NGS) (ChIP-seq) using FFPE samples has been established, removal of interference signals from non-target cell components in the samples is still needed. In this study, the protocol of ChIP-seq with purified cells from FFPE lymphoid tissue of nodal T follicular helper cell lymphoma, angioimmunoblastic type (nTFHL-AI) after fluorescence-activated cell sorting (FACS) was established and optimized.
View Article and Find Full Text PDFCarbohydr Polym
March 2025
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources and International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, China. Electronic address:
The inverse electron demand Diels-Alder (IEDDA) cycloaddition between tetrazines and strained dienophiles is recognized as a fast and specific reaction. The integrating tetrazines and strained dienophiles onto the backbone of polysaccharides yield appropriate water-soluble precursors for IEDDA cycloaddition. Due to the high specificity of the IEDDA reaction and its outstanding cytocompatibility, a range of cargos (live cells, peptides and pharmaceuticals) can be effectively encapsulated in polysaccharide solutions throughout the hydrogel formation.
View Article and Find Full Text PDFBiol Psychiatry
January 2025
Psychiatry and Neuroscience Departments, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York City, NY, 10029; Psychiatry and Neuroscience Departments, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York City, NY, 10029. Electronic address:
Background: Valid scalable biomarkers for predicting longitudinal clinical outcomes in psychiatric research are crucial for optimizing intervention and prevention efforts. Here we recorded spontaneous speech from initially abstinent individuals with cocaine use disorder (iCUD) for use in predicting drug use outcomes.
Methods: At baseline, 88 iCUD provided 5-minute speech samples describing the positive consequences of quitting drug use and negative consequences of using drugs.
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