AI Article Synopsis
- The study focuses on the management of complex open fractures (Gustilo-Anderson IIIB) with significant tissue loss, using a local antibiotic hydroxyapatite bio-composite.
- In a retrospective review of 81 patients, the treatment resulted in a 96% union rate, a 96.3% limb salvage rate, and only a 3.7% rate of deep infection over an average follow-up of 55.8 months.
- The findings suggest that combining local antibiotic therapy with a "fix and flap" approach leads to favorable outcomes, but further research is recommended to assess functional and quality of life impacts.
Article Abstract
Background Open fractures associated with significant tissue loss are complex and present challenges in management; they are associated with poor outcomes such as infection, non-union or amputation. This study aimed to evaluate outcomes of using an adjuvant local antibiotic hydroxyapatite bio-composite in the management of open Gustilo-Anderson IIIB fractures with up to eight years of follow-up. Methods This was a retrospective study. A total of 81 patients with Gustilo-Anderson IIIB fractures treated with "fix and flap" limb reconstruction with adjuvant local antibiotic therapy using a bio-composite carrier were reviewed. Results The mean follow-up time for all the patients, at the time of data collection, was 55.8 months. Union was achieved in 96% with a limb salvage rate of 96.3% and a deep infection rate of 3.7%. Conclusion The use of local antibiotic therapy, together with a combined orthoplastic "fix and flap" approach for Gustilo-Anderson IIIB open fractures, was found to be associated with a very low rate of metalwork infection and high union and limb salvage rates. Future studies should include some functional and quality of life outcome measures to see the efficacy of this method.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270668 | PMC |
| http://dx.doi.org/10.7759/cureus.39103 | DOI Listing |
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