Trisomy 21, or Down syndrome (DS), is neonates' most common chromosomal abnormality. In addition, children born with DS have an increased risk of congenital anomalies such as congenital heart defects, gastrointestinal abnormalities, and, rarely, cleft palate. Cleft lip and palate are among the most common congenital anomalies associated with many congenital syndromes; however, Trisomy 21 is the least common congenital anomaly associated with orofacial clefts. We present a case of cleft palate, duodenal stenosis, persistent pulmonary hypertension of the newborn, patent ductus arteriosus, and atrial septal defect in a newborn with classical clinical features of Down syndrome. This report discusses the uncommon presentation of trisomy 21 and concomitant cleft palate in a neonate, including its recognition and treatment, as no standard of care treatment exists.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270723PMC
http://dx.doi.org/10.7759/cureus.39107DOI Listing

Publication Analysis

Top Keywords

cleft palate
16
congenital anomalies
8
common congenital
8
cleft
5
congenital
5
palate newborn
4
trisomy
4
newborn trisomy
4
trisomy case
4
case report
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!