Cancer Lett
Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China. Electronic address:
Published: July 2023
Protein tyrosine phosphatase receptor-type O (PTPRO) is a membrane-bound tyrosine phosphatase. Notably, epigenetically silenced PTPRO due to promoter hypermethylation is frequently linked to malignancies. In this study, we used cellular and animal models, and patient samples to demonstrate that PTPRO can suppress the metastasis of esophageal squamous cell carcinoma (ESCC). Mechanistically, PTPRO can inhibit MET-mediated metastasis by dephosphorylating Y1234/1235 in the kinase activation loop of MET. Patients with PTPRO/p-MET had significantly poor prognosis, suggesting that PTPRO/p-MET can serve as an independent prognostic factor for patients with ESCC.
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http://dx.doi.org/10.1016/j.canlet.2023.216283 | DOI Listing |
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