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Anti-inflammatory activity and selective inhibition of iNOS gene expression by a polyherbal formulation.
J Ayurveda Integr Med
January 2025
Institute of Biochemistry, Molecular Biology and Biotechnology (IBMBB), University of Colombo, Sri Lanka.
Background: Link Samahan® (LS), a product of Link Natural Products (Pvt) Limited, Sri Lanka contains extracts of 14 medicinal plants. It is used as a prophylactic against cold and cold related symptoms. It has immunomodulatory activity, specifically enhancing the humoral immune response.
View Article and Find Full Text PDFStandardized protocol during acetabular fracture surgery results in low rates of heterotopic ossification.
Eur J Orthop Surg Traumatol
December 2024
University of Washington Department of Orthopaedic Surgery and Sports Medicine, 1959 NE Pacific St, Seattle, WA, 98195, USA.
Purpose: To assess the rate of heterotopic ossification (HO) following acetabular surgery with a standardized protocol via the Kocher-Langenbeck. Secondarily, to evaluate patient characteristics, injury variables, and perioperative data among patients with HO and no HO.
Methods: This was a retrospective case series from an academic Level I trauma center.
Use of NSAIDs and acetaminophen and risk of spontaneous intestinal perforations in premature infants: a systematic review and meta-analysis.
Front Pediatr
November 2024
Department of OBGYN, Newborn Division, University of Ottawa, The Ottawa Hospital, Ottawa, ON, Canada.
Background: Acquired spontaneous intestinal perforation or SIP occurs most commonly in the extremely premature infant population. As the incidence is rising, understanding modifiable factors such as common medication exposures becomes important for individualizing care.
Methods: The primary outcome was SIP in premature infants with exposure to indomethacin, ibuprofen, or acetaminophen.
Prophylactic low-dose hydrocortisone in neonates born extremely preterm: current knowledge and future challenges.
Pediatr Res
November 2024
Neonatal Intensive Care Unit, Saint Vincent de Paul Hospital, GHICL, Lille, France.
Article Synopsis
- * Research shows that this treatment can lower mortality rates, improve chances of survival without BPD, and support heart function and urine output, but there are concerns about risks like intestinal perforation and late-onset infections, especially in very premature infants.
- * While long-term developmental outcomes appear unaffected, ongoing discussions focus on the ideal patient population, timing, duration of treatment, and obstacles to applying this treatment as guidelines evolve.
Preventive Measures and Risk Factors for Post-ERCP Pancreatitis: A Systematic Review and Individual Patient Data Meta-Analysis.
Dig Dis Sci
December 2024
Department of Gastroenterology and Hepatology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GM, Nijmegen, Netherlands.
Background: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is the most common complication of ERCP, with limited studies comparing combined prophylactic measures and their efficacy relative to individual patient risk profiles. This study aims to perform an individual patient data meta-analysis (IPDMA) to evaluate the contribution of patient and ERCP-related risk factors to PEP development and to identify the best prophylaxis strategies according to the patient's risk profile.
Methods: We systematically searched MEDLINE, Embase, and Cochrane databases until November 2022 for randomized controlled PEP prophylaxis trials.
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