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Clinical efficacy of platelet-rich fibrin, injectable platelet-rich fibrin, and advanced platelet-rich fibrin in regenerative endodontics: A case series.
J Conserv Dent Endod
November 2024
Department of Conservative Dentistry and Endodontics, Inderprastha Dental College and Hospital, Ghaziabad, Uttar Pradesh, India.
Background: This series investigates the efficacy of regenerative endodontic therapy (RET) using various platelet-rich fibrin (PRF) formulations in treating apical periodontitis and necrotic pulp in immature permanent teeth.
Aim: This study aims to evaluate the effectiveness of different PRF formulations in RET.
Materials And Methods: Three cases involving patients aged 15-16 with immature teeth and necrotic pulp were treated with RET using PRF, injectable PRF, and advanced PRF.
Immature granulocytes as an early clinical predictor in children with respiratory syncytial virus bronchiolitis.
Pediatr Int
December 2024
Department of Pediatrics, Bursa Faculty of Medicine, City Training and Research Hospital, University of Health Sciences, Bursa, Turkey.
Background: Immature granulocytes can be measured easily in a complete blood count by new automated hemolytic analyzers and have recently been studied as bio-markers in many infectious/inflammatory diseases. This study aims to investigate whether immature granulocyte percentage (IG%) would enable greater discrimination than conventionally utilized laboratory values in terms of early clinical prediction in instances with respiratory syncytial virus (RSV) bronchiolitis.
Methods: A prospective observational cohort study involved 149 individuals with RSV bronchiolitis.
Absolute Immature Platelet Count: An Accessible Biomarker to Distinguish Aplastic Anemia and Immune Thrombocytopenia.
Int J Lab Hematol
December 2024
Division of Hematology-Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Unlabelled: Megakaryocytes (MKs) are large, polyploid cells that contribute to bone marrow homeostasis through the secretion of cytokines such as transforming growth factor β1 (TGFβ1). During neoplastic transformation, immature MKs accumulate in the bone marrow where they induce fibrotic remodeling ultimately resulting in myelofibrosis. Current treatment strategies aim to prevent MK hyperproliferation, however, little is understood about the potential of targeting dysregulated cytokine secretion from neoplastic MKs as a novel therapeutic avenue.
View Article and Find Full Text PDFImpaired hemostatic and immune functions of platelets after acute thrombocytopenia.
J Thromb Haemost
December 2024
Institute of Vascular Biology and Thrombosis Research, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria. Electronic address:
Background: Platelets are pivotal in maintaining vascular integrity, hemostasis, and immune modulation, with newly generated, immature platelets being the most responsive in fulfilling these tasks. Therefore, the immature platelet fraction provides insights into thrombopoiesis dynamics and clinical prognostication. However, it is currently unclear how immature platelet functions change in settings of acute thrombocytopenia.
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