AI Article Synopsis
- The study focuses on Plasmodium ovale wallikeri, a parasite that causes relapses in humans similar to Plasmodium vivax, where infections can recur after a dormant phase in the liver.
- Researchers analyzed relapse patterns in travelers who contracted the parasite in sub-Saharan Africa and experienced these relapses after returning to France.
- Using genetic markers, they found that most primary infections and relapses were genetically similar, providing the first genetic evidence of relapses in P ovale species.
Article Abstract
Like Plasmodium vivax, both Plasmodium ovale curtisi and Plasmodium ovale wallikeri have the ability to cause relapse in humans, defined as recurring asexual parasitemia originating from liver-dormant forms subsequent to a primary infection. Here, we investigated relapse patterns in P ovale wallikeri infections from a cohort of travelers who were exposed to the parasite in sub-Saharan Africa and then experienced relapses after their return to France. Using a novel set of 8 highly polymorphic microsatellite markers, we genotyped 15 P ovale wallikeri relapses. For most relapses, the paired primary and relapse infections were highly genetically related (with 12 being homologous), an observation that was confirmed by whole-genome sequencing for the 4 relapses we further studied. This is, to our knowledge, the first genetic evidence of relapses in P ovale spp.
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| http://dx.doi.org/10.1093/infdis/jiad216 | DOI Listing |
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