Previous studies of nonlinear oscillator networks have shown that amplitude death (AD) occurs after tuning oscillator parameters and coupling properties. Here, we identify regimes where the opposite occurs and show that a local defect (or impurity) in network connectivity leads to AD suppression in situations where identically coupled oscillators cannot. The critical impurity strength value leading to oscillation restoration is an explicit function of network size and system parameters. In contrast to homogeneous coupling, network size plays a crucial role in reducing this critical value. This behavior can be traced back to the steady-state destabilization through a Hopf's bifurcation, which occurs for impurity strengths below this threshold. This effect is illustrated across different mean-field coupled networks and is supported by simulations and theoretical analysis. Since local inhomogeneities are ubiquitous and often unavoidable, such imperfections can be an unexpected source of oscillation control.
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http://dx.doi.org/10.1103/PhysRevE.107.054207 | DOI Listing |
Am Heart J
January 2025
Clinical and Experimental Interventional Cardiology, University of Saarland, Homburg, Germany.
Background And Rationale: In-stent restenosis (ISR) remains the leading cause of treatment failure following percutaneous coronary intervention (PCI) with contemporary drug-eluting stents. Especially in small caliber coronary arteries, restenosis is common following PCI and represents a treatment challenge. Drug-coated balloons (DCB) are an attractive alternative to stents for treatment of both ISR and small vessel disease.
View Article and Find Full Text PDFJ Pharmacol Sci
February 2025
Department of Pharmacology, Showa University Graduate School of Pharmacy, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan; Pharmacological Research Center, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan.
Diabetic retinopathy (DR) is the leading cause of blindness among working-age adults, and inflammation and oxidative stress contribute to DR development. However, no effective treatments are currently approved for DR. Therefore, this study aimed to investigate the effects of SMTP-44D-a Stachybotrys microspora-derived compound with anti-inflammatory and antioxidant properties-on DR in in vivo and in vitro models.
View Article and Find Full Text PDFForensic Sci Int
January 2025
Department of Forensic Medicine, Soochow University, Ganjiang East Road, Suzhou, Jiangsu, China. Electronic address:
Necrophagous blow flies are a commonly used forensic tool to estimate the minimum postmortem interval (PMI), where researchers collect development data under constant temperature regimes and construct models to estimate PMI. However, the ambient temperatures of real death scenes are often fluctuant, which limits the reliability of data obtained under constant temperature regimes. Here we investigate the possible differences in the development of Chrysomya megacephala (Fabricius, 1794) (Diptera: Calliphoridae), an important species in forensic entomology.
View Article and Find Full Text PDFAm J Cardiovasc Drugs
January 2025
Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, China.
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies (mAbs) have demonstrated promising effects in lowering cardiovascular incidents among patients with acute coronary syndrome. However, their influence on early platelet reactivity after primary percutaneous coronary intervention (PPCI) remains unclear.
Objectives: This research sought to investigate the effects of entirely human anti-PCSK9 antibodies on platelet function as measured by thrombelastography and 12-month postoperative results in patients receiving PPCI and treated with ticagrelor-based dual antiplatelet therapy.
Adv Mater
January 2025
State Key Laboratory of Fine Chemicals, Department of Pharmacy, School of Chemical Engineering, Dalian University of Technology, Dalian, 116024, China.
Phytochlorins, a class of plant-derived tetrapyrroles, show great potential as sonosensitizers in sonodynamic therapy (SDT). The development of new phytochlorin-based sonosensitizers has significantly improved SDT, yet the absence of specialized sonodynamic systems limits their clinical translation. Herein, a dedicated ultrasound system along with a detailed step-by-step sonodynamic process from in vitro to in vivo is developed to activate phytochlorin-based sonosensitizers.
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