Packings of beads confined in slowly tilted containers with a top free surface are commonly used in laboratory experiments to model natural grain avalanches and better understand and predict critical events from optical measurements of the surface activity. To that aim, after reproducible packing preparations, the present paper focuses on the effects of the surface fabrication, which can be scraped or soft leveled, on both the avalanche stability angle and the dynamic of precursory events for glass beads of 2-mm diameter. A depth effect of a scraping operation is highlighted by considering different packing heights and inclination speeds.
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http://dx.doi.org/10.1103/PhysRevE.107.054906 | DOI Listing |
Discov Nano
January 2025
Institute of Medical Research, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, 710072, Shaanxi, China.
Human lens epithelial cells (hLECs) are critical for lens transparency, and their aberrant metabolic activity and gene expression can lead to cataract. Intracellular delivery to hLECs, especially to sub-cellular organelles (e.g.
View Article and Find Full Text PDFLangmuir
January 2025
Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Nucleic Acids, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China.
Surface antigen-directed immunotherapy is a curative treatment modality for acute myeloid leukemia (AML) that is characterized by the abundance and stability expression of surface antigens. However, current surface antigen-directed immunotherapies have shown poor outcomes and undesirable mortality rates in treating AML patients, primarily due to acquired resistance that arises from using single-target therapies to address the heterogeneous expression of surface antigens. Hence, in order to improve the efficacy of antigen-specific therapies for treating AML, we designed a bispecific aptamer-drug conjugate.
View Article and Find Full Text PDFLangmuir
January 2025
Department of Physics, SRM University AP Andhra Pradesh, Mangalagiri, Andhra Pradesh 522502, India.
This article reports facile fabrication of a multifunctional smart surface having superhydrophobic self-cleaning property, superoleophilicity, and antimicrobial property. These smart surfaces have been synthesized using the stereolithography (SLA) method of the additive manufacturing technique. SLA is a fast additive manufacturing technique used to create complex parts with intricate geometries.
View Article and Find Full Text PDFProtein Sci
February 2025
Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), San Sebastián, Spain.
Enzyme immobilization is indispensable for enhancing enzyme performance in various industrial applications. Typically, enzymes require specific spatial arrangements for optimal functionality, underscoring the importance of correct orientation. Despite well-known N- or C-terminus tailoring techniques, alternatives for achieving orientation control are limited.
View Article and Find Full Text PDFACS Sens
January 2025
Department of Electrical and Computer Engineering, Missouri University of Science and Technology, Rolla, Missouri 65409, United States.
Wearable sensors are increasingly being used as biosensors for health monitoring. Current wearable devices are large, heavy, invasive, skin irritants, or not continuous. Miniaturization was chosen to address these issues, using a femtosecond laser-conversion technique to fabricate miniaturized laser-induced graphene (LIG) sensor arrays on and encapsulated within a polyimide substrate.
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