The roughness of a fracture surface records a crack's complex path through a material and can affect the resultant frictional or fluid transport properties of the broken medium. For brittle fractures, some of the most prominent surface features are long, step-like discontinuities called step lines. In heterogeneous materials, the mean crack surface roughness created by these step lines is well captured by a simple, one-dimensional ballistic annihilation model, which assumes the creation of these steps is a random processes with a single probability that depends on the heterogeneity of the material, and that their destruction occurs via pairwise interactions. Here, through an exhaustive study of experimentally generated crack surfaces in brittle hydrogels, we examine step interactions and show that interaction outcomes depend on the geometry of the incoming steps. The rules that govern step interactions can be categorized into three unique classes and are fully described, providing a complete framework for predicting fracture roughness.
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http://dx.doi.org/10.1103/PhysRevE.107.055003 | DOI Listing |
Eur J Med Chem
January 2025
University of Pisa, Department of Chemistry and Industrial Chemistry, Via G. Moruzzi 13, I-56124, Pisa, Italy. Electronic address:
The novel diiron amine complexes [FeCp(CO)(NHR')(μ-CO){μ-CN(Me)(Cy)}]CFSO [R' = H, 3; Cy, 4; CHCHNH, 5; CHCHNMe, 6; CHCH(4-CHOMe), 7; CHCH(4-CHOH), 8; Cp = η-CH, Cy = CH = cyclohexyl] were synthesized in 49-92 % yields from [FeCp(CO)(μ-CO){μ-CN(Me)(Cy)}]CFSO, 1a, using a straightforward two-step procedure. They were characterized by IR and multinuclear NMR spectroscopy, and the structure of 7 was confirmed through X-ray diffraction analysis. Complexes 3-8 and the acetonitrile adducts [FeCp(CO)(NCMe)(μ-CO){μ-CN(Me)(R)}]CFSO (R = Cy, 2a; Me, 2b; Xyl = 2,6-CHMe, 2c) were assessed for their water solubility, octanol-water partition coefficient and stability in physiological-like solutions.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
2-arachnadoyl glycerol (2-AG) is one of the most common endocannabinoid molecules with anti-proliferative, cytotoxic, and pro-proliferative effects on different types of tumors. Typically, it induces cell death via cannabinoid receptor 1/2 (CB1/CB2)-linked ceramide production. In breast cancer, ceramide is counterbalanced by the sphingosine-1-phosphate, and thus the mechanisms of 2-AG influence on proliferation are poorly understood.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Research Institute of Chemistry, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.
In this study, we report the first example of acyclic (amino)(N-pyridinium)carbenoid gold(III) complexes synthesized via a coupling reaction between 2-pyridylselenyl chloride and Au(I)-bound isonitriles. The reaction involves an initial oxidative addition of the Se-Cl moiety to Au(I), followed by the nucleophilic addition of the pyridine fragment to the isonitrile's C≡N bond, furnishing a metallacycle. Importantly, this is the first example of the pyridine acting as a nucleophile towards metal-bound isonitriles.
View Article and Find Full Text PDFMicromachines (Basel)
December 2024
Research Laboratory "Sensor Systems Based on Integrated Photonics Devices", Ufa University of Science and Technology, 32, Z. Validi St., Ufa 450076, Russia.
Radio photonic technologies have emerged as a promising solution for addressing microwave frequency synthesis challenges in current and future communication and sensing systems. One particularly effective approach is the optoelectronic oscillator (OEO), a simple and cost-effective electro-optical system. The OEO can generate microwave signals with low phase noise and high oscillation frequencies, often outperforming traditional electrical methods.
View Article and Find Full Text PDFRegul Toxicol Pharmacol
January 2025
Corteva Agriscience, Zuid-Oostsingel 24D, Bergen op Zoom, 4611 BB, the Netherlands.
Environmental Safety Assessments (ESA) are mandatory for several regulatory purposes and are an important component of stewardship/sustainability initiatives. Fish testing is used for assessing chemical toxicity and bioaccumulation potential; amphibians are included in some jurisdictions and their use is increasing to assess endocrine disruption. Alternative methods are becoming more available, covering the principles of the 3Rs (i.
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