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Maximal Intensity Exercise Induces Adipokine Secretion and Disrupts Prooxidant-Antioxidant Balance in Young Men with Different Body Composition.
Int J Mol Sci
January 2025
Department of Sports Medicine and Human Nutrition, Institute of Biomedical Sciences, Faculty of Physical Education and Sport, University of Physical Education in Kraków, 31-571 Kraków, Poland.
Maximal physical effort induces a disturbance in the body's energy homeostasis and causes oxidative stress. The aim of the study was to determine whether prooxidant-antioxidant balance disturbances and the secretion of adipokines regulating metabolism, induced by maximal intensity exercise, are dependent on body composition in young, healthy, non-obese individuals. We determined changes in the concentration of advanced protein oxidation products (AOPP), markers of oxidative damage to nucleic acids (DNA/RNA/ox), and lipid peroxidation (LPO); catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activity, as well as concentrations of visfatin, leptin, resistin, adiponectin, asprosin, and irisin in the blood before and after maximal intensity exercise in men with above-average muscle mass (NFAT-HLBM), above-average fat mass (HFAT-NLBM), and with average body composition (NFAT-NLBM).
View Article and Find Full Text PDFCorrelation between polymorphisms of gene and renal injury in patients with type 2 diabetes mellitus.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
July 2024
Department of Nephrology, Third Xiangya Hospital, Central South University, Changsha 410013.
Objectives: Genetic factors play an important role in the pathogenesis of diabetic kidney disease (DKD). Studies have shown that gene polymorphism is associated with the pathogenesis of type 2 diabetes mellitus (T2DM), but its role in DKD remains unclear. This study aims to analyze the distribution of alleles and genotypes of gene in patients with T2DM, and investigate the association between genetic polymorphism and DKD susceptibility in T2DM patients, which may provide new ideas for the pathogenesis of DKD.
View Article and Find Full Text PDFAssociation of Polymorphism in Locus of rs274503 (/) with the Risk of Idiopathic Clubfoot in Chinese Children: An 11-Center Case-Control Study.
Genet Test Mol Biomarkers
December 2024
Department of Pediatric Orthopedics, Guangzhou Women and Children's Medical Centre, Guangzhou Medical University, Guangzhou, China.
Article Synopsis
- Idiopathic clubfoot (IC) can be initially corrected with the Ponseti method, but often recurs, potentially due to various unknown genetic and environmental factors, including a specific genetic marker (rs274503) found in Caucasian children.
- An 11-center study involving 516 IC patients and 661 healthy children in China identified that the G variant of rs274503 is linked to a higher risk of developing IC, particularly in cases with bilateral involvement.
- While the G variant of rs274503 was associated with increased IC risk, the results were not significant in all genetic models, indicating the need for more research to validate these findings.
Metformin improves HPRT1-targeted purine metabolism and repairs NR4A1-mediated autophagic flux by modulating FoxO1 nucleocytoplasmic shuttling to treat postmenopausal osteoporosis.
Cell Death Dis
November 2024
Department of Orthopedics, First Hospital of China Medical University, Shenyang, China.
Osteoporosis is a major degenerative metabolic bone disease that threatens the life and health of postmenopausal women. Owing to limitations in detection methods and prevention strategy awareness, the purpose of osteoporosis treatment is more to delay further deterioration rather than to fundamentally correct bone mass. We aimed to clarify the pathogenesis of postmenopausal osteoporosis and optimize treatment plans.
View Article and Find Full Text PDFKinetic Analysis and Metabolism of Poly(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted F-Fluorthanatrace PET in Breast Cancer.
J Nucl Med
December 2024
Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;
The poly(adenosine diphosphate-ribose) polymerase inhibitors (PARPi) have demonstrated efficacy in ovarian, breast, and prostate cancers, but current biomarkers do not consistently predict clinical benefit. F-fluorthanatrace (F-FTT) is an analog to rucaparib, a clinically approved PARPi, and is a candidate biomarker for PARPi response. This study intends to characterize F-FTT pharmacokinetics in breast cancer and optimize image timing for clinical trials.
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