AI Article Synopsis
- Recent evidence highlights the significant role of commensal microbiota in both health and disease, particularly in relation to cerebrovascular diseases like stroke.
- Gut microbes influence bodily functions by metabolizing dietary factors and host substrates, which can lead to the production of both beneficial and harmful compounds.
- This review discusses how gut dysbiosis contributes to cerebrovascular diseases and post-stroke cognitive issues, emphasizing potential therapeutic strategies that target microbiota to improve health outcomes.
Article Abstract
In recent years, increasing evidence suggests that commensal microbiota may play an important role not only in health but also in disease including cerebrovascular disease. Gut microbes impact physiology, at least in part, by metabolizing dietary factors and host-derived substrates and then generating active compounds including toxins. The purpose of this current review is to highlight the complex interplay between microbiota, their metabolites. and essential functions for human health, ranging from regulation of the metabolism and the immune system to modulation of brain development and function. We discuss the role of gut dysbiosis in cerebrovascular disease, specifically in acute and chronic stroke phases, and the possible implication of intestinal microbiota in post-stroke cognitive impairment and dementia, and we identify potential therapeutic opportunities of targeting microbiota in this context. LINKED ARTICLES: This article is part of a themed issue From Alzheimer's Disease to Vascular Dementia: Different Roads Leading to Cognitive Decline. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v181.6/issuetoc.
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