AI Article Synopsis
- MiR-204-5p is identified as a down-regulated tumor suppressor in papillary thyroid carcinoma (PTC) tissues, with lower levels found in patients who also have benign lesions.
- Research shows that miR-204-5p can inhibit cancer cell proliferation, migration, and invasion while promoting cell death.
- The protein AP1S2 is a target of miR-204-5p, suggesting it plays a significant role in the development of PTC through the miR-204-5p/AP1S2 pathway.
Article Abstract
MiR-204-5p, as a tumour suppressor, has been found in several cancers. However, whether miR-204-5p is involved in papillary thyroid carcinoma (PTC) has not yet been investigated. In this study, we identified miR-204-5p as a down-regulated miRNA in PTC tissues, unveiling that the levels of miR-204-5p in serum of patients with PTC were linked to PTC risk, and that the expression in patients concomitant with both PTC and benign lesions was much lower than that in patients only with PTC. Furthermore, we documented that miR-204-5p inhibited proliferation, migration, invasion, and cell cycle progression and triggered apoptosis of PTC cells via cell biology experiments. Finally, we identified that AP1S2 was a target of miR-204-5p using RNA-seq, iTRAQ, and bioinformatics prediction. Overall, miR-204-5p functions as a suppressor for PTC pathogenesis via the miR-204-5p/AP1S2 axis.
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| http://dx.doi.org/10.1016/j.mce.2023.111993 | DOI Listing |
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