Management of splenic cysts in children remains undefined. Sclerotherapy is an innovative, less invasive treatment. This study examined the safety and preliminary effectiveness of sclerotherapy for splenic cysts in children compared with those of surgical treatment. A retrospective review of pediatric patients treated for nonparasitic splenic cysts from 2007 to 2021 was performed at a single institution. Posttreatment outcomes for patients who underwent either expectant management, sclerotherapy, or surgery were reviewed. Thirty patients aged between 0 and 18 years met the inclusion criteria. Cysts in 3 of 8 patients who underwent sclerotherapy were either unresolved or recurred. Patients who underwent sclerotherapy and required surgery for residual symptomatic cyst had an initial cyst diameter of >8 cm. Symptoms resolved in 5 of 8 patients who underwent sclerotherapy, with a significantly reduced cyst size compared with that in patients with continued symptoms who underwent sclerotherapy (61.4% vs 7.0%, P = .01). Sclerotherapy is an effective treatment for splenic cysts, particularly those measuring <8 cm. However, surgical excision may be preferable for large cysts.
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http://dx.doi.org/10.1016/j.jvir.2023.06.012 | DOI Listing |
Cureus
December 2024
Research Institute, Medical University of Pleven, Pleven, BGR.
Splenic cysts are rare medical conditions, and their incidence is dominated by parasitic types. Non-parasitic splenic cysts, whether true cysts (with a cellular lining of the cystic wall) or pseudocysts (without a cellular lining), are significantly rarer than parasitic ones. Their etiology is not fully established, with fetal remnant development, metaplasia, and mesothelial invagination being widely accepted possible mechanisms.
View Article and Find Full Text PDFInfect Dis Clin Microbiol
December 2024
Department of General Surgery, Çanakkale Onsekiz Mart University School of Medicine, Çanakkale, Türkiye.
Objective: Cystic echinococcosis (CE) caused by the larval stage of the parasite is a global health problem. This study aimed to assess cases of CE admitted to our General Surgery Department retrospectively, as there is no known similar publication concerning surgical treatment of abdominal cystic echinococcosis in Çanakkale province.
Materials And Methods: We analyzed laboratory and radiological findings alongside clinical and demographic features, treatments, and outcomes of cases undergoing surgical treatment for abdominal cystic echinococcosis in our department between 2012 and 2022.
Introduction: Primary mucinous cystadenoma is a very rare lesion in the spleen, with only a few reported cases available in the literature. Ectopic pancreatic or enteric tissue and invaginated splenic capsular epithelium are assumed to be the origin of mucinous cystadenomas of the spleen. We present the first reported case in Ethiopia.
View Article and Find Full Text PDFCells
December 2024
Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA.
We recently identified that the cerebral mRNA expression of inducible costimulator (ICOS) and its ligand, ICOSL, both significantly increase during the elimination of cysts from the brains of infected mice by the perforin-mediated cytotoxic activity of CD8 T cells. In the present study, we examined the role of ICOS in activating the effector activity of CD8 T cells in response to the presence of cysts in infected mice. Following the adoptive transfer of splenic CD8 T cells from chronically infected ICOS-deficient (ICOS) and wild-type (WT) mice to infected SCID mice, fewer CD8 T cells were detected in the brains of the recipients of ICOS CD8 T cells than the recipients of WT CD8 T cells.
View Article and Find Full Text PDFCureus
November 2024
Pathology, Avalon University School of Medicine, Willemstad, CUW.
Splenic cysts, although rare, present a diagnostic and therapeutic challenge due to their varied etiologies and clinical manifestations. This review synthesizes the current understanding of splenic cysts through an analysis of thirteen case reports spanning from 1988 to 2023. Etiologies include epithelial, parasitic, and sarcomatous origins.
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