Ataxin-2, an RNA-binding protein that is conserved across eukaryotes, is involved in stress granule assembly and age-associated neurodegenerative diseases. In this issue of Molecular Cell, Boeynaems et al. identify a short linear motif in ataxin-2 as a condensation switch, providing molecular insights into its essential role in cellular stress response.
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| http://dx.doi.org/10.1016/j.molcel.2023.05.024 | DOI Listing |
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