The study of how the number of spikes in a middle temporal visual area (MT/V5) neuron is tuned to the direction of a visual stimulus has attracted considerable attention over the years, but recent studies suggest that the variability of the number of spikes might also be influenced by the directional stimulus. This entails that Poisson regression models are not adequate for this type of data, as the observations usually present over/underdispersion (or both) with respect to the Poisson distribution. This paper makes use of the double exponential family and presents a flexible model to estimate, jointly, the mean and dispersion functions, accounting for the effect of a circular covariate. The empirical performance of the proposal is explored via simulations and an application to a neurological data set is shown.
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http://dx.doi.org/10.1111/biom.13882 | DOI Listing |
Epilepsy Res
January 2025
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea.
Objective: This study aimed to assess the long-term outcome and prognostic factors of vagus nerve stimulation (VNS) for drug-resistant epilepsy (DRE) using real-world data.
Method: We included 189 DRE patients who underwent VNS implantation between 2005 and 2018 at nine national hospitals in Korea. Seizure-frequency data obtained quarterly one year before and after surgery and annually up to four years after surgery were collected from medical records.
Front Cell Infect Microbiol
January 2025
College of Basic Medical Sciences, School of Medicine, Zhejiang University, Hangzhou, China.
Introduction: Coronavirus disease 2019 (COVID-19) is characterized by fever, fatigue, dry cough, dyspnea, mild pneumonia and acute lung injury (ALI), which can lead to acute respiratory distress syndrome (ARDS), and SARS-CoV-2 can accelerate tumor progression. However, the molecular mechanism for the increased mortality in cancer patients infected with COVID-19 is unclear.
Methods: Colony formation and wound healing assays were performed on Huh-7 cells cocultured with syncytia.
BMC Ophthalmol
January 2025
Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Purpose: Proliferative vitreoretinopathy (PVR) is a complication of retinal detachment which requires multiple vitreoretinal surgical interventions and frequent use of oil endotamponade. In this study, we conducted an in-depth analysis of complications associated with the use of heavy silicone oil in the management of inferior PVR.
Methods: A retrospective cohort study of 20 eyes that underwent vitrectomy for inferior PVR with use of heavy silicone oil (Densiron 68) between March 2021 and October 2022 at Oxford Eye Hospital.
Behav Res Methods
January 2025
Methods Center, Eberhard Karls University of Tübingen, Haußerstr. 11, 72076, Tübingen, Germany.
Due to the increased availability of intensive longitudinal data, researchers have been able to specify increasingly complex dynamic latent variable models. However, these models present challenges related to overfitting, hierarchical features, non-linearity, and sample size requirements. There are further limitations to be addressed regarding the finite sample performance of priors, including bias, accuracy, and type I error inflation.
View Article and Find Full Text PDFPLOS Glob Public Health
January 2025
Public Health Agency of Sweden, Solna, Sweden.
Acute SARS-CoV-2 infections are not always diagnosed; hence an unknown proportion of all infections are not documented. SARS-CoV-2 can induce spike and nucleocapsid protein specific IgG antibodies, which can be detected in seroprevalence studies to identify a previous infection. However, with the introduction of vaccines containing the spike protein it is no longer possible to use spike-IgG as a marker of infection.
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