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Drug Development.
Alzheimers Dement
December 2024
National Institute on Aging, NIH, Baltimore, MD, USA.
Background: Epidemiological studies report an elevated risk of neurodegenerative disorders, particularly Parkinson's disease (PD), in patients with type 2 diabetes mellitus (T2DM) that is mitigated in those prescribed incretin mimetics or dipeptidyl peptidase 4 inhibitors (DPP-4Is). Incretin mimetic repurposing appears promising in human PD and Alzheimer's disease (AD) clinical trials. DPP-4Is are yet to be evaluated in PD or AD human studies.
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Alzheimers Dement
December 2024
Vanderbilt University Medical Center, Nashville, TN, USA.
Background: We report the case of a 79-year-old woman with Alzheimer's disease who enrolled in a clinical study of lecanemab. After the third, biweekly infusion she suffered a seizure followed by aphasia and progressive encephalopathy. Magnetic resonance imaging revealed multifocal cerebral edema and an increased burden of cerebral microhemorrhages compared to pre-trial imaging.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Centre for Research in Aging - Donald Berman Maimonides Geriatric Centre, Montreal, QC, Canada.
Background: Screening for elder abuse can cause victims to experience feelings of unpleasantness and/or relive painful memories which can be an ethical concern. Ensuring the safety of all participants/users, in our case long-term care (LTC) residents, is of the utmost importance.
Method: Drawing from approaches used in the intimate partner violence and clinical trials literature, we developed a novel typology of harm and a series of procedures to evaluate any negative consequences that might be incurred as a result of participating in the Piloting the Elder Abuse Suspicion Index-long term care: A Mixed Methods Feasibility Study.
Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
NYU School of Medicine, New York, NY, USA.
Background: In the United States, approximately 2 million caregivers of people with Alzheimer's disease or related dementia (ADRD) are Latin American. As many of these caregivers are family or friends, most are not equipped with the tools necessary to address common behaviors associated with ADRD. Music-based interventions are an effective and accessible tool to assist caregivers in addressing these persistent behaviors.
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Alzheimers Dement
December 2024
University of Southern California, Los Angeles, OH, USA.
Background: Family caregivers to persons living with dementia are at risk of financial strain from the high out-of-pocket costs of care and reduced employment opportunities. Financial strain disproportionately affects U.S.
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