• DMS has a high morbidity and a 5-year mortality rate of >50%. • DMS frequently occurs as mixed mitral disease as well as multivalvular disease. • Assessment of severity requires use of TTE, TEE, and stress echocardiography. • CT is used for periprocedural planning. • Treatment can be surgical or transcatheter.
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http://dx.doi.org/10.1016/j.case.2022.12.014 | DOI Listing |
Radiographics
January 2024
From the Departments of Radiology (K.G.S., R.K.V., A.A.A.B., M.Z., M.U.A., M.L.R.) and Nephrology (A.A.A.B.), University of Alabama at Birmingham, 619 19th St S, Birmingham, AL 35233; and Department of Radiology, Mayo Clinic, Jacksonville, Fla (L.F.A., D.M.S., M.P.C., M.J.C.).
Patients with kidney failure require kidney replacement therapy. While renal transplantation remains the treatment of choice for kidney failure, renal replacement therapy with hemodialysis may be required owing to the limited availability and length of time patients may wait for allografts or for patients ineligible for transplant owing to advanced age or comorbidities. The ideal hemodialysis access should provide complication-free dialysis by creating a direct connection between an artery and vein with adequate blood flow that can be reliably and easily accessed percutaneously several times a week.
View Article and Find Full Text PDFRadiographics
October 2022
From the Departments of Radiology (L.F.A., C.J.O., D.M.S., M.J.C., A.M.M., M.P.C.) and Vascular Surgery (Y.M.E.), Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224; and Department of Radiology, University of Alabama Birmingham, Birmingham, Ala (M.L.R.).
Ruptured abdominal aortic aneurysm (AAA) carries high morbidity and mortality. Elective repair of AAA with endovascular stent-grafts requires lifetime imaging surveillance for potential complications, most commonly endoleaks. Because endoleaks result in antegrade or retrograde systemic arterialized flow into the excluded aneurysm sac, patients are at risk for recurrent aneurysm sac growth with the potential to rupture.
View Article and Find Full Text PDFBiomech Model Mechanobiol
December 2022
Department of Engineering, Rangos School of Health Sciences, Duquesne University, 413 Libermann Hall, 600 Forbes Avenue, Pittsburgh, PA, 15282, USA.
In this study, the biomechanical role of intraluminal thrombus (ILT) in an abdominal aortic aneurysm (AAA) is investigated. The implications of ILT in AAA are controversial in literature. Previous studies have demonstrated that ILT provides a biomechanical advantage by decreasing wall stress, whereas other studies have associated ILT with inhibiting oxygen transport and inducing aortic wall weakening.
View Article and Find Full Text PDFNat Biotechnol
April 2022
Divisions of Oncology and of Hematology, Department of Medicine, Stanford School of Medicine, Stanford, CA, USA.
Profiling of circulating tumor DNA (ctDNA) in the bloodstream shows promise for noninvasive cancer detection. Chromatin fragmentation features have previously been explored to infer gene expression profiles from cell-free DNA (cfDNA), but current fragmentomic methods require high concentrations of tumor-derived DNA and provide limited resolution. Here we describe promoter fragmentation entropy as an epigenomic cfDNA feature that predicts RNA expression levels at individual genes.
View Article and Find Full Text PDFAm J Nucl Med Mol Imaging
June 2021
Department of Radiology and Imaging Sciences, Emory University Hospital 1364 Clifton Road, Atlanta, GA 30322, USA.
Monitoring therapeutic response in patients with metastatic castration-resistant prostate cancer (mCRPC) can be challenging. We set out to determine if F-fluciclovine PET/CT could be a useful imaging biomarker for response to docetaxel chemotherapy in patients with mCRPC. Seven patients with mCRPC had F-fluciclovine PET/CT scheduled at baseline and after 1 and 6 cycles of chemotherapy.
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