Introduction: Postoperative Atrial Fibrillation (POAF) is a common complication of cardiac surgery, associated with increased mortality, stroke risk, cardiac failure and prolonged hospital stay. Our study aimed to assess the patterns of release of systemic cytokines in patients with and without POAF.

Methods: A post-hoc analysis of the Remote Ischemic Preconditioning (RIPC) trial, including 121 patients (93 males and 28 females, mean age of 68 years old) who underwent isolated coronary artery bypass grafting (CABG) and aortic valve replacement (AVR). Mixed-effect models were used to analyze patterns of release of cytokines in POAF and non-AF patients. A logistic regression model was used to assess the effect of peak cytokine concentration (6 h after the aortic cross-clamp release) alongside other clinical predictors on the development of POAF.

Results: We found no significant difference in the patterns of release of IL-6 ( = 0.52), IL-10 ( = 0.39), IL-8 ( = 0.20) and TNF-α ( = 0.55) between POAF and non-AF patients. Also, we found no significant predictive value in peak concentrations of IL-6 ( = 0.2), IL-8 ( = >0.9), IL-10 ( = >0.9) and Tumour Necrosis Factor Alpha (TNF-α)( = 0.6), however age and aortic cross-clamp time were significant predictors of POAF development across all models.

Conclusions: Our study suggests no significant association exists between cytokine release patterns and the development of POAF. Age and Aortic Cross-clamp time were found to be significant predictors of POAF.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266410PMC
http://dx.doi.org/10.3389/fsurg.2023.1205396DOI Listing

Publication Analysis

Top Keywords

patterns release
12
aortic cross-clamp
12
cytokine release
8
atrial fibrillation
8
poaf non-af
8
non-af patients
8
age aortic
8
cross-clamp time
8
time predictors
8
predictors poaf
8

Similar Publications

A hyperelastic torque-reversal mechanism for soft joints with compression-responsive transient bistability.

Sci Robot

January 2025

Biorobotics Laboratory, Soft Robotics Research Center, Institute of Advanced Machines and Design, Department of Mechanical Engineering, Institute of Engineering, Seoul National University, Seoul, Republic of Korea.

Snap-through, a rapid transition of a system from an equilibrium state to a nonadjacent equilibrium state, is a valuable design element of soft devices for converting a monolithic stimulus into systematic responses with impulsive motions. A common way to benefit from snap-through is to embody it within structures and materials, such as bistable structures. Torque-reversal mechanisms discovered in nature, which harness snap-through instability via muscular forces, may have comparative advantages.

View Article and Find Full Text PDF

Environmental fate and aquatic risk assessment of oxyfluorfen in California rice fields.

Integr Environ Assess Manag

January 2025

Department of Environmental Toxicology, College of Agricultural and Environmental Sciences, University of California, Davis, CA, United States.

The herbicide oxyfluorfen [OXY; 2-chloro-1-(3-ethoxy-4-nitrophenoxy)-4-(trifluoromethyl)benzene] recently emerged as a potential solution to combat herbicide resistance in California rice. Proposed as a preemergent applied preflood to soil, products are in development for use with OXY-tolerant rice strains. Currently, OXY is not registered for use with rice and its use in or near aquatic resources is restricted due to its high aquatic toxicity.

View Article and Find Full Text PDF
Article Synopsis
  • Smoking is a significant public health issue in Tamil Nadu, causing preventable diseases and increasing healthcare costs, necessitating effective smoking cessation strategies in primary health care (PHC) settings.
  • The study aims to evaluate the cost-effectiveness of three proposed smoking cessation strategies against the current standard strategy, focusing on various combinations of counseling, nicotine replacement therapy, and medications for smokers aged 15 and older.
  • Results indicated that the current cessation strategy was more expensive than the proposed strategies, with two of them (PS1 and PS3) being more cost-effective, potentially leading to better resource allocation for smoking cessation efforts.
View Article and Find Full Text PDF

The broader use of botanical pesticides has been limited by shorter residual activity on plants, slower onset of action, and higher costs compared with conventional pesticides. These challenges could be overcome by the development of simple, cost-effective, and long-lasting preventive nanocomposites for botanical pesticides. In this study, we successfully developed a low-cost ethyl cellulose (EC)-based delivery system for the botanical pesticide osthole (OST), designed to provide extended preventive protection against infestations.

View Article and Find Full Text PDF

In cardiovascular research, electromagnetic fields generated by Riga plates are utilized to study or manipulate blood flow dynamics, which is particularly crucial in developing treatments for conditions such as arterial plaque deposition and understanding blood behavior under varied flow conditions. This research predicts the flow patterns of blood enhanced with gold and maghemite nanoparticles (gold-maghemite/blood) in an electromagnetic microchannel influenced by Riga plates with a temperature gradient that decays exponentially, under sudden changes in pressure gradient. The flow modeling includes key physical influences like radiation heat emission and Darcy drag forces in porous media, with the flow mathematically represented through unsteady partial differential equations solved using the Laplace transform (LT) method.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!