Vinyl ether based macro-chain transfer agents (m-CTAs) are used to produce different di or tri-block copolymers under catalytic living ROMP conditions. Polystyrene (PS) vinyl ether m-CTA and polycaprolactone (PCL) or polylactide vinyl ether (PLA) m-CTAs are synthesized straightforwardly ATRP and ROP respectively. Regioselectivity as well as the high metathesis activity of these m-CTAs enabled us to synthesise a range of metathesis-based A-B diblock copolymers with controlled dispersities ( < 1.4). In this manner, PS-ROMP (here, ROMP refers to a poly(MNI--DHF) block), PCL-ROMP and PLA-ROMP were synthesized using substoichiometric amounts of ruthenium complex in a living fashion. Also, a more complex PEG-PCL-ROMP tri-block terpolymer was obtained catalytically. All block copolymers were characterized by SEC and DOSY NMR spectroscopy. We believe that this methodology of using macro-chain transfer agents to prepare degradable ROMP polymers under catalytic living ROMP conditions will find applications in biomedicine.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262279 | PMC |
| http://dx.doi.org/10.1039/d3py00387f | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Production of abiotic or biogenic hydrocarbons on rock particles in the presence of HO and carbon compounds.
Sci Rep
January 2025
Climate and Environmental Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, 02792, Republic of Korea.
Abiotic H and hydrocarbons are found in fluids discharged from ultramafic-hosted hydrothermal vents. Beneath the hydrothermal vents, abiotic H and hydrocarbons can be formed by serpentinization reactions and Fischer-Tropsch-type hydrocarbon-forming reactions, respectively, over ultramafic rocks. However, the source rocks that form abiotic H and hydrocarbons may extend to broader subsurface rocks.
View Article and Find Full Text PDFDendritic Platinum Nanoparticles Shielded by Pt-S PEGylation as Intracellular Reactors for Bioorthogonal Uncaging Chemistry.
Angew Chem Int Ed Engl
January 2025
University of Edinburgh, Edinburgh Cancer Research, Crewe Road South, Institute of Genetics and Cancer, EH4 2XR, Edinburgh, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
Beyond their classical role as cytotoxics, Platinum (Pt) coordination complexes recently joined the selected group of transition metals capable of performing bioorthogonal reactions in living environments. To minimize their reactivity towards nucleophiles, which limit their catalytic performance, we investigated the use of Pt(0) with different forms, sizes and surface functionalization. We report herein the development of PEGylated Pt nanodendrites with the capacity to activate prodyes and prodrugs in cell culture and in vivo.
View Article and Find Full Text PDFAll-In-One Entropy-Driven DNA Nanomachine for Tumor Cell-Selective Fluorescence/SERS Dual-Mode Imaging of MicroRNA.
Anal Chem
January 2025
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, PR China.
An entropy-driven catalysis (EDC) strategy is appealing for amplified bioimaging of microRNAs in living cells; yet, complex operation procedures, lacking of cell selectivity, and insufficient accuracy hamper its further applications. Here, we introduce an ingenious all-in-one entropy-driven DNA nanomachine (termed as AIO-EDN), which can be triggered by endogenous apurinic/apyrimidinic endonuclease 1 (APE1) to achieve tumor cell-selective dual-mode imaging of microRNA. Compared with the traditional EDC strategy, the integrated design of AIO-EDN achieves autocatalytic signal amplification without extra fuel strands.
View Article and Find Full Text PDFLuminescent cyclometalated gold(iii) complexes covalently linked to metal-organic frameworks for heterogeneous photocatalysis.
Chem Sci
December 2024
Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong Pokfulam Road Hong Kong P. R. China
Phosphorescent gold(iii) complexes possess long-lived emissive excited states, making them ideal for use as molecular sensors and photosensitizers for organic transformations. Literature reports indicate that gold(iii) emitters exhibit good catalytic activity in homogeneous photochemical reactions. Heterogeneous metal-organic framework (MOF)-supported gold(iii) photocatalysts are considered to show high recyclability in photochemical reactions and potentially provide new selectivities.
View Article and Find Full Text PDFSeroprevalence, incidence estimates, and environmental risk factors for dengue, chikungunya, and Zika infection amongst children living in informal urban settlements in Indonesia and Fiji.
BMC Infect Dis
January 2025
Faculty of Medicine, Center for Zoonotic and Emerging Diseases HUMRC, Universitas Hasanuddin, Makassar, Indonesia.
Background: The burden of Aedes aegypti-transmitted viruses such as dengue, chikungunya, and Zika are increasing globally, fueled by urbanization and climate change, with some of the highest current rates of transmission in Asia. Local factors in the built environment have the potential to exacerbate or mitigate transmission.
Methods: In 24 informal urban settlements in Makassar, Indonesia and Suva, Fiji, we tested children under 5 years old for evidence of prior infection with dengue, chikungunya, and Zika viruses by IgG serology.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!