In this paper, we study the global stability and persistence of a microorganism flocculation model with infinite delay. First, we make a complete theoretical analysis on the local stability of the boundary equilibrium (microorganism-free equilibrium) and the positive equilibrium (microorganism co-existent equilibrium), and give a sufficient condition for the global stability of the boundary equilibrium (applicable to the forward bifurcation and the backward bifurcation). Then, for the persistence of the model, we present an explicit estimate of the eventual lower bound of any positive solution for which only the parameter threshold $ R_0 > 1 $ is required. The obtained results extend some of the conclusions of the existing literatures on the case of discrete time delay.
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Background: In the United States, complete abstinence persists as the standard for demonstrating recovery success from substance use disorders (SUDs), apart from alcohol use disorder (AUD). Although the FDA has recently indicated openness for non-abstinence outcomes as treatment targets, the traditional benchmark of complete abstinence for new medications to treat SUDs remains a hurdle and overshadows other non-abstinent outcomes desired by people with SUDs (e.g.
View Article and Find Full Text PDFMath Biosci
January 2025
Department of Applied Mathematics, The Hong Kong Polytechnic University, Hong Kong, China. Electronic address:
Worldwide amphibian decline and extinction have been observed, highlighting the importance of identifying the underlying factors. This issue has long been recognized as highly significant and continues to receive substantial attention in conservation ecology. Pathogen infection, in particular the chytrid fungus Batrachochytrium dendrobatidis, is postulated as a key factor contributing to the decline of certain species within specific regions.
View Article and Find Full Text PDFGene
January 2025
State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, China. Electronic address:
Advances in molecular medicine and biotechnology have demonstrated messenger RNA (mRNA)-based therapies to be a promising therapeutic modality for infectious diseases, genetic disorders, and cancers. However, key challenges persist, including low translation efficiency and short half-life of exogenous mRNA. The untranslated regions (UTRs) influence important parameters like mRNA stability and translation efficiency.
View Article and Find Full Text PDFJ Hazard Mater
January 2025
Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fujian, Fuzhou 350108, China. Electronic address:
Phenolic compounds are a kind of persistent organic pollutants (POPs), which are always a threat to human and environment due to their strong toxicity and low biodegradability. Therefore, developing a reliable method to simultaneously detect phenolic pollutants is of great importance to environmental safety and human health. Herein, we combined the advantages of metal organic frameworks (MOFs) and covalent organic frameworks (COFs) to prepare two cyclic trinuclear unit-based metal covalent organic framework (MCOFs, denoted as Cu-TDH COF and Cu-BDU COF) with large specific surface area, good stability and excellent laccase-like activity.
View Article and Find Full Text PDFJ ECT
November 2024
Department of Psychiatry and Health Behavior, Medical College of Georgia at Augusta University, Augusta, GA.
Electroconvulsive therapy (ECT) is underused, logistically challenging for those who are justice-involved, and laced with ethical problems for those on death row. Herein we describe a case of a man without history of long-standing psychiatric illness who, after more than 15 years on death row, was hospitalized for altered mental status. After medical stabilization, the altered mental status persisted.
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