Surgical management for treatment-resistant cases of inflammatory exudative retinal detachment: Mission impossible?

Indian J Ophthalmol

Department of Uvea and Intraocular Inflammation, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India.

Published: June 2023

Purpose: To report the outcome of surgical intervention for inflammatory, exudative retinal detachment (ERD).

Methods: A retrospective analysis of eyes with ERD that underwent vitrectomy.

Results: Twelve eyes (10 patients) with ERD, non-responsive to medical therapy, underwent vitrectomy. The mean age was 35.7 ± 17.7 years. Five eyes (42%) had Vogt-Koyanagi-Harada disease, three (25%) had presumed tuberculosis (TB), two (17%) pars planitis, and one (8%) had sympathetic ophthalmia. The mean time of vitrectomy was 6.76 ± 4.1 months after onset. Six (50%) eyes had a recurrence, two settled with medical treatment, and four underwent re-surgery. The mean follow-up was 2.7 years. At the last visit, 10 (83.3%) eyes had attached retina; the best-corrected visual acuity (BCVA) had reduced to 1.6 ± 0.7 logarithms of the minimum angle of resolution (logMAR) from 1.3 ± 0.7 at baseline.

Conclusion: Vitrectomy in ERD can act as an adjuvant to conventional medical therapy and help maintain structural integrity. Early vitrectomy may help preserve visual function.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418000PMC
http://dx.doi.org/10.4103/IJO.IJO_2575_22DOI Listing

Publication Analysis

Top Keywords

inflammatory exudative
8
exudative retinal
8
retinal detachment
8
medical therapy
8
eyes
5
surgical management
4
management treatment-resistant
4
treatment-resistant cases
4
cases inflammatory
4
detachment mission
4

Similar Publications

Absorbable Meek skin graft material transplantation: A preliminary experimental study.

Burns

January 2025

Jiangsu Tech-Bio-Med Medical Equipment Co.,Ltd., Changzhou, Jiangsu 213000, China.

Background: Wound closure is the core issue in treating patients with extensive burns. Allogeneic grafts can serve as a suitable temporary substitute in third-degree burns, and the Meek technique has provided encouraging outcomes in recent decades. However, whether allografts and the Meek technique could be used simultaneously so as to leverage the strengths of both has not been extensively examined.

View Article and Find Full Text PDF

Purpose: To report a case of persistent bilateral sclerouveitis following bilateral bimatoprost implantation (Durysta) that required implant removal and oral steroid course.

Observation: A 75-year-old Caucasian male with no prior ocular inflammation experienced bilateral sclerouveitis post bilateral bimatoprost implantation. Despite implant removal from both eyes, the ocular inflammation persisted, showing cystoid macular edema in both eyes and exudative retinal detachment in the right.

View Article and Find Full Text PDF

Asperulosidic acid inhibits the PI3K/Akt/NF-κB pathway to suppress endotoxin-induced uveitis.

Front Med (Lausanne)

January 2025

Department of Ophthalmology, Chongqing Key Laboratory for the Prevention and Treatment of Major Blinding Eye Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Introduction: Uveitis, a severe inflammatory disease affecting the uvea, is associated with visual impairment and irreversible blindness. Asperulosidic Acid (ASPA), derived from , is known for its notable anti-inflammatory and antioxidant characteristics.

Methods: The present study explored the potential anti-inflammatory effects and the fundamental processes of ASPA by injecting it or a placebo into the vitreous of rats with endotoxin-induced uveitis (EIU).

View Article and Find Full Text PDF

Background: Anterior uveitis is a common manifestation in individuals with rheumatic conditions such as spondylarthritis, Behçet's syndrome, juvenile idiopathic arthritis, and sarcoidosis. Clinical differentiation between granulomatous and non-granulomatous corneal endothelial exudates is crucial to subsequent diagnosis and treatment. Anterior segment optical coherence tomography (AS-OCT) can ensure an accurate differential diagnosis and appropriate follow-up after local and systemic therapy.

View Article and Find Full Text PDF

Hereditary vitreoretinopathies (HVRs), also known as hereditary vitreoretinal degenerations comprise a heterogeneous group of inherited disorders of the retina and vitreous, collectively and variably characterised by vitreal abnormalities, such as fibrillary condensations, liquefaction or membranes, as well as peripheral retinal abnormalities, vascular changes in some, an increased risk of retinal detachment and early-onset cataract formation. The pathology often involves the vitreoretinal interface in some, while the major underlying abnormality is vascular in others. Recent advances in molecular diagnosis and identification of the responsible genes and have improved our understanding of the pathogenesis, risks and management of the HVRs.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!