AI Article Synopsis
- Triple-negative breast cancer (TNBC) is a serious health issue for women, and this study investigates the role of lncRNA SNHG11 in its progression.
- Researchers measured the levels of SNHG11, microRNA-7-5p, specificity protein 2 (SP2), and mucin 1 (MUC-1) in TNBC tissues and cells to understand their relation to cancer behaviors.
- The findings show that SNHG11 promotes malignant behaviors in TNBC cells by regulating SP2 and MUC-1, making this research a significant first step in exploring the role of lncRNA SNHG11 in TNBC.
Article Abstract
Triple-negative breast cancer (TNBC) seriously affects woman's health. The present work is to study the working mechanism of lncRNA SNHG11 in TNBC. The expressions of SNHG11, microRNA (miR)- 7-5p, specificity protein 2 (SP2) and mucin 1 (MUC-1) in TNBC tissues and cells were detected. SNHG11, miR-7-5p and SP2 expressions were then evaluated for TNBC cell malignant behaviors. The relationships among SNHG11, miR-7-5p and SP2 were predicted and verified. Finally, the binding of the transcription factor SP2 to MUC-1 promoter was detected. Abnormally elevated SNHG11, SP2 and MUC-1 expressions were observed in cultured TNBC cells and tumor tissues. SNHG11 knockdown in TNBC cells. Silencing SP2 weakened the promoting effect of SNHG11 on TNBC progression. SNHG11 negatively regulated miR-7-5p expression and positively regulated SP2 expression. SP2 bound to the P2 site of MUC-1 promoter, and SP2 knockdown suppressed MUC-1 expression. It was demonstrated that lncRNA SNHG11 promoted TNBC cell malignant behaviors to facilitate TNBC progression. The study is first of its kinds to unravel the potential of lncRNA SNHG11 in relation to TNBC.
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| http://dx.doi.org/10.1016/j.prp.2023.154578 | DOI Listing |
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