AI Article Synopsis
- Researchers developed 2-Hydroxy-4-morpholin-2,5-diarylfuran-3(2)-one derivatives using methyl ketones and morpholine as starting materials through a combination of iodine and zinc dust in a one-pot synthesis.
- The synthesis occurred under mild conditions and successfully formed various chemical bonds including carbon-carbon (C-C), carbon-nitrogen (C-N), and carbon-oxygen (C-O) bonds.
- A notable achievement of this process was the construction of a quaternary carbon center while incorporating the morpholine fragment, which is significant for drug development.
Article Abstract
2-Hydroxy-4-morpholin-2,5-diarylfuran-3(2)-one derivatives were constructed sequentially using iodine and zinc dust from simple and readily available methyl ketone and morpholine as the starting materials. Under mild conditions, C-C, C-N, and C-O bonds formed in a one-pot synthesis. A quaternary carbon center was successfully constructed, and the active drug fragment morpholine was introduced into the molecule.
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| http://dx.doi.org/10.1021/acs.joc.3c00885 | DOI Listing |
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