A one-pot synthesis of 2,4-disubstituted quinazoline derivatives from halofluorobenzenes with nitriles was reported, sequential nucleophilic addition and SAr reaction. The advantages of the present approach are transition metal free, easy to operate, and all the starting materials are commercially available.
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| http://dx.doi.org/10.1039/d3ob00741c | DOI Listing |
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