Major advances in genomics have dramatically increased our understanding of Fuchs endothelial corneal dystrophy (FECD) and identified diverse genetic causes and associations. Biomarkers derived from these studies have the potential to inform both clinical treatment and yield novel therapeutics for this corneal dystrophy.
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| http://dx.doi.org/10.1097/ICO.0000000000003292 | DOI Listing |
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Imaging pathology in archived cornea with Fuchs' endothelial corneal dystrophy including tissue reprocessing for volume electron microscopy.
Sci Rep
December 2024
Structural Biophysics Research Group, School of Optometry & Vision Sciences, Cardiff University, Cardiff, Wales, UK.
Fuchs' endothelial corneal dystrophy (FECD) is a common sight-threatening condition characterised by pathological changes in the posterior cornea. Here we report observations by light, transmission and volume scanning electron microscopy on changes in the endothelium and matrix associated with the characteristic deformations of Descemet's membrane, termed guttae. Specimens were archived full-thickness human corneal tissue, removed during graft surgery, that had been fixed, stained and embedded by conventional processing methods for examination by transmission electron microscopy more than 40-years previously.
View Article and Find Full Text PDFDelayed spontaneous resolution of a double anterior chamber following deep anterior lamellar keratoplasty (DALK).
BMC Ophthalmol
December 2024
Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
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Predicting corneal decompensation in Fuchs endothelial corneal dystrophy with Scheimpflug tomography and clinical parameters.
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Department of Ophthalmology, Université Paris Cité, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
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View Article and Find Full Text PDFGenetic variants in PIKFYVE: A review of ocular phenotypes.
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Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Canada. Electronic address:
Article Synopsis
- A review highlights various disease-causing variants of the gene PIKFYVE found in ocular tissues and their associated eye conditions, filling a gap in existing research.
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